Trefoil Factor Family (TFF) Peptides and Their Links to Inflammation: A Re-evaluation and New Medical Perspectives.
FCGBP
gastric cancer
inflammation
innate immunity
lectin
macrophages
mucin
reactive oxygen species
receptor blocking
trefoil factor
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
06 May 2021
06 May 2021
Historique:
received:
07
04
2021
revised:
21
04
2021
accepted:
21
04
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
23
6
2021
Statut:
epublish
Résumé
Trefoil factor family peptides (TFF1, TFF2, TFF3), together with mucins, are typical exocrine products of mucous epithelia. Here, they act as a gastric tumor suppressor (TFF1) or they play different roles in mucosal innate immune defense (TFF2, TFF3). Minute amounts are also secreted as endocrine, e.g., by the immune and central nervous systems. As a hallmark, TFF peptides have different lectin activities, best characterized for TFF2, but also TFF1. Pathologically, ectopic expression occurs during inflammation and in various tumors. In this review, the role of TFF peptides during inflammation is discussed on two levels. On the one hand, the expression of TFF1-3 is regulated by inflammatory signals in different ways (upstream links). On the other hand, TFF peptides influence inflammatory processes (downstream links). The latter are recognized best in various
Identifiants
pubmed: 34066339
pii: ijms22094909
doi: 10.3390/ijms22094909
pmc: PMC8125380
pii:
doi:
Substances chimiques
Inflammation Mediators
0
Trefoil Factors
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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