ANGPTL3 Variants Associate with Lower Levels of Irisin and C-Peptide in a Cohort of Arab Individuals.
ANGPTL3-DOCK7
Arab population
c-peptide
insulin resistance
interleukin 13
irisin
lipid metabolism
triglyceride
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
17 05 2021
17 05 2021
Historique:
received:
10
04
2021
revised:
11
05
2021
accepted:
12
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
25
8
2021
Statut:
epublish
Résumé
ANGPTL3 is an important regulator of lipid metabolism. Its inhibition in people with hypercholesteremia reduces plasma lipid levels dramatically. Genome-wide association studies have associated ANGPTL3 variants with lipid traits. Irisin, an exercise-modulated protein, has been associated with lipid metabolism. Intracellular accumulation of lipids impairs insulin action and contributes to metabolic disorders. In this study, we evaluate the impact of ANGPTL3 variants on levels of irisin and markers associated with lipid metabolism and insulin resistance. ANGPTL3 rs1748197 and rs12130333 variants were genotyped in a cohort of 278 Arab individuals from Kuwait. Levels of irisin and other metabolic markers were measured by ELISA. Significance of association signals was assessed using Bonferroni-corrected
Identifiants
pubmed: 34067751
pii: genes12050755
doi: 10.3390/genes12050755
pmc: PMC8170900
pii:
doi:
Substances chimiques
ANGPTL3 protein, human
0
Angiopoietin-Like Protein 3
0
Angiopoietin-like Proteins
0
C-Peptide
0
FNDC5 protein, human
0
Fibronectins
0
Interleukin-13
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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