Beneficial Effects of Metformin on the Central Nervous System, with a Focus on Epilepsy and Lafora Disease.
AMPK
GPD2
Lafora disease
epilepsy
mechanism of action
metformin
neurological disorders
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
19 May 2021
19 May 2021
Historique:
received:
20
04
2021
revised:
12
05
2021
accepted:
17
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
3
7
2021
Statut:
epublish
Résumé
Metformin is a drug in the family of biguanide compounds that is widely used in the treatment of type 2 diabetes (T2D). Interestingly, the therapeutic potential of metformin expands its prescribed use as an anti-diabetic drug. In this sense, it has been described that metformin administration has beneficial effects on different neurological conditions. In this work, we review the beneficial effects of this drug as a neuroprotective agent in different neurological diseases, with a special focus on epileptic disorders and Lafora disease, a particular type of progressive myoclonus epilepsy. In addition, we review the different proposed mechanisms of action of metformin to understand its function at the neurological level.
Identifiants
pubmed: 34069559
pii: ijms22105351
doi: 10.3390/ijms22105351
pmc: PMC8160983
pii:
doi:
Substances chimiques
Hypoglycemic Agents
0
Neuroprotective Agents
0
Metformin
9100L32L2N
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NINDS NIH HHS
ID : P01 NS097197
Pays : United States
Organisme : Ministerio de Ciencia e Innovación
ID : Rti2018-095784b-100 SAF
Organisme : NIH HHS
ID : P01 NS097197
Pays : United States
Organisme : Ministerio de Ciencia e Innovación
ID : SAF2017-83151-R
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