The CD200 Regulates Inflammation in Mice Independently of TNF-α Production.
Animals
Antigens, CD
/ genetics
Colitis
/ pathology
Colon
/ pathology
Cytokines
/ metabolism
Endothelial Cells
/ metabolism
Female
Gene Expression
/ genetics
Gene Expression Regulation
/ genetics
Inflammation
/ genetics
Inflammatory Bowel Diseases
/ metabolism
Macrophages
/ metabolism
Male
Membrane Glycoproteins
/ metabolism
Mice
Mice, Inbred C57BL
Mice, Knockout
Receptors, Immunologic
/ metabolism
Tumor Necrosis Factor-alpha
/ immunology
CD200
CD200R
immune regulation
inflammation
inflammatory bowel disease
myeloid cells
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
19 May 2021
19 May 2021
Historique:
received:
15
03
2021
revised:
06
05
2021
accepted:
14
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
3
7
2021
Statut:
epublish
Résumé
Inflammatory bowel disease is characterized by the infiltration of immune cells and chronic inflammation. The immune inhibitory receptor, CD200R, is involved in the downregulation of the activation of immune cells to prevent excessive inflammation. We aimed to define the role of CD200R ligand-CD200 in the experimental model of intestinal inflammation in conventionally-reared mice. Mice were given a dextran sodium sulfate solution in drinking water. Bodyweight loss was monitored daily and the disease activity index was calculated, and a histological evaluation of the colon was performed. TNF-α production was measured in the culture of small fragments of the distal colon or bone marrow-derived macrophages (BMDMs) cocultured with CD200
Identifiants
pubmed: 34069671
pii: ijms22105358
doi: 10.3390/ijms22105358
pmc: PMC8161250
pii:
doi:
Substances chimiques
Antigens, CD
0
CD200 receptor, mouse
0
Cytokines
0
Membrane Glycoproteins
0
Receptors, Immunologic
0
Tumor Necrosis Factor-alpha
0
antigens, CD200
UQ4V77A8VA
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fundacja na rzecz Nauki Polskiej
ID : HOMING PLUS/2011-4/10
Organisme : Narodowe Centrum Nauki
ID : 2014/15/B/NZ6/03716
Références
J Immunol. 2003 Sep 15;171(6):3034-46
pubmed: 12960329
Nat Immunol. 2008 Sep;9(9):1074-83
pubmed: 18660812
Mucosal Immunol. 2013 May;6(3):498-510
pubmed: 22990622
Sci Rep. 2016 Nov 07;6:36457
pubmed: 27819346
J Immunol. 2006 Jan 1;176(1):191-9
pubmed: 16365410
Gastroenterology. 2006 Jun;130(7):1962-74
pubmed: 16762619
J Immunol. 2010 Jun 15;184(12):6843-54
pubmed: 20483766
mBio. 2016 Feb 16;7(1):e01670-15
pubmed: 26884432
J Innate Immun. 2010;2(2):195-200
pubmed: 20375636
J Immunol. 2009 Aug 1;183(3):1990-6
pubmed: 19587022
Gut. 1993 Dec;34(12):1705-9
pubmed: 8031350
Immunol Rev. 2014 Jul;260(1):102-17
pubmed: 24942685
Immunology. 1981 Dec;44(4):727-36
pubmed: 6119291
J Clin Immunol. 1996 May;16(3):144-50
pubmed: 8734357
Eur J Gastroenterol Hepatol. 2000 Mar;12(3):267-73
pubmed: 10750645
Immunity. 2011 Feb 25;34(2):237-46
pubmed: 21333554
Am J Pathol. 2002 Nov;161(5):1669-77
pubmed: 12414514
J Anat. 2009 Jan;214(1):183-95
pubmed: 19166481
Am J Pathol. 2007 Aug;171(2):580-8
pubmed: 17600119
Lab Invest. 1993 Aug;69(2):238-49
pubmed: 8350599
J Leukoc Biol. 2014 Mar;95(3):531-41
pubmed: 24212097
J Immunol. 2004 Dec 1;173(11):6786-93
pubmed: 15557172
Nat Immunol. 2014 Oct;15(10):929-937
pubmed: 25151491
Adv Immunol. 2014;121:191-211
pubmed: 24388216
Exp Anim. 2001 Oct;50(5):387-95
pubmed: 11769541
Immunobiology. 2012 Jun;217(6):643-51
pubmed: 22204814
J Clin Invest. 2008 Jun;118(6):2269-80
pubmed: 18497880
J Innate Immun. 2011;3(6):550-64
pubmed: 22025201
Cell Host Microbe. 2011 Jun 16;9(6):463-71
pubmed: 21669395
Immunity. 2000 Aug;13(2):233-42
pubmed: 10981966
J Immunol. 2004 Sep 15;173(6):3748-54
pubmed: 15356121
World J Gastroenterol. 2014 Jan 7;20(1):91-9
pubmed: 24415861
Int Immunopharmacol. 2016 Jan;30:74-84
pubmed: 26655877
Cancer Immunol Res. 2018 Aug;6(8):930-940
pubmed: 30021725
Scand J Gastroenterol. 2007 Nov;42(11):1312-20
pubmed: 17852866
Clin Lab. 2016 Aug 1;62(8):1521-1529
pubmed: 28164626
Eur J Immunol. 2010 Sep;40(9):2569-79
pubmed: 20662098
PLoS Pathog. 2012;8(5):e1002710
pubmed: 22615569
PLoS One. 2016 Feb 03;11(2):e0146681
pubmed: 26841120
Cell Host Microbe. 2010 Sep 16;8(3):236-47
pubmed: 20833375
Sci Rep. 2020 Apr 8;10(1):6078
pubmed: 32269253
J Biomed Biotechnol. 2012;2012:718617
pubmed: 22665990
Gut Pathog. 2015 Dec 21;7:32
pubmed: 26697117
Immunol Today. 1994 Feb;15(2):74-80
pubmed: 7512342
PLoS One. 2012;7(2):e31671
pubmed: 22363701
Immunity. 2014 May 15;40(5):706-19
pubmed: 24792912
Immunology. 2001 Feb;102(2):173-9
pubmed: 11260322
Nat Med. 2013 Jun;19(6):713-21
pubmed: 23708291
J Biol Chem. 2010 Jun 18;285(25):19593-604
pubmed: 20388715
J Neurochem. 1984 Oct;43(4):1061-7
pubmed: 6147390
Int J Mol Sci. 2015 Dec 04;16(12):28998-9010
pubmed: 26690123