The Metabolomic-Gut-Clinical Axis of Mankai Plant-Derived Dietary Polyphenols.
Mediterranean diet
Wolffia globosa
flavonoids
plant-based nutrition
polyphenols
weight loss
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
30 May 2021
30 May 2021
Historique:
received:
10
05
2021
revised:
26
05
2021
accepted:
27
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
29
7
2021
Statut:
epublish
Résumé
Polyphenols are secondary metabolites produced by plants to defend themselves from environmental stressors. We explored the effect of We used mass-spectrometry-based metabolomics methods from three laboratories to detect Mankai phenolic metabolites and examined predicted functional pathways in a Mankai artificial-gut bioreactor. Plasma and urine polyphenols were assessed among the 294 DIRECT-PLUS 18-month trial participants, comparing the effect of a polyphenol-rich green-Mediterranean diet (+1240 mg/polyphenols/day, provided by Mankai, green tea and walnuts) to a walnuts-enriched (+440 mg/polyphenols/day) Mediterranean diet and a healthy controlled diet. Approximately 200 different phenolic compounds were specifically detected in the Mankai plant. The Mankai-supplemented bioreactor artificial gut displayed a significantly higher relative-abundance of 16S-rRNA bacterial gene sequences encoding for enzymes involved in phenolic compound degradation. In humans, several Mankai-related plasma and urine polyphenols were differentially elevated in the green Mediterranean group compared with the other groups ( The Mankai new plant is rich in various unique potent polyphenols, potentially affecting the metabolomic-gut-clinical axis.
Sections du résumé
BACKGROUND
BACKGROUND
Polyphenols are secondary metabolites produced by plants to defend themselves from environmental stressors. We explored the effect of
METHODS
METHODS
We used mass-spectrometry-based metabolomics methods from three laboratories to detect Mankai phenolic metabolites and examined predicted functional pathways in a Mankai artificial-gut bioreactor. Plasma and urine polyphenols were assessed among the 294 DIRECT-PLUS 18-month trial participants, comparing the effect of a polyphenol-rich green-Mediterranean diet (+1240 mg/polyphenols/day, provided by Mankai, green tea and walnuts) to a walnuts-enriched (+440 mg/polyphenols/day) Mediterranean diet and a healthy controlled diet.
RESULTS
RESULTS
Approximately 200 different phenolic compounds were specifically detected in the Mankai plant. The Mankai-supplemented bioreactor artificial gut displayed a significantly higher relative-abundance of 16S-rRNA bacterial gene sequences encoding for enzymes involved in phenolic compound degradation. In humans, several Mankai-related plasma and urine polyphenols were differentially elevated in the green Mediterranean group compared with the other groups (
CONCLUSIONS
CONCLUSIONS
The Mankai new plant is rich in various unique potent polyphenols, potentially affecting the metabolomic-gut-clinical axis.
Identifiants
pubmed: 34070816
pii: nu13061866
doi: 10.3390/nu13061866
pmc: PMC8229908
pii:
doi:
Substances chimiques
Polyphenols
0
Tea
0
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : project no. 209933838, grant SFB1052
Organisme : Ministry of Health, State of Israel
ID : 87472511
Organisme : Ministry of Science and Technology, Israel
ID : 3-13604
Organisme : California Walnut Commission
ID : NA
Organisme : Hinoman LTD
ID : NA
Organisme : Arizona-BGU collaborative grant
ID : NA
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