Genetic Predisposition to the Mortality in Septic Shock Patients: From GWAS to the Identification of a Regulatory Variant Modulating the Activity of a
Alleles
Biomarkers
Computational Biology
/ methods
Enhancer Elements, Genetic
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Interleukin-6
/ blood
Molecular Sequence Annotation
Polymorphism, Single Nucleotide
Prognosis
Protein Interaction Mapping
Protein Interaction Maps
ROC Curve
Regulatory Sequences, Nucleic Acid
Reproducibility of Results
Shock, Septic
/ etiology
Suppressor of Cytokine Signaling Proteins
/ genetics
CISH
CRISPR-Cas9
GWAS
SNPs
enhancer
luciferase assay
non coding region
sepsis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
29 May 2021
29 May 2021
Historique:
received:
23
04
2021
revised:
12
05
2021
accepted:
17
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
22
6
2021
Statut:
epublish
Résumé
The high mortality rate in septic shock patients is likely due to environmental and genetic factors, which influence the host response to infection. Two genome-wide association studies (GWAS) on 832 septic shock patients were performed. We used integrative bioinformatic approaches to annotate and prioritize the sepsis-associated single nucleotide polymorphisms (SNPs). An association of 139 SNPs with death based on a false discovery rate of 5% was detected. The most significant SNPs were within the
Identifiants
pubmed: 34072601
pii: ijms22115852
doi: 10.3390/ijms22115852
pmc: PMC8198806
pii:
doi:
Substances chimiques
Biomarkers
0
Interleukin-6
0
Suppressor of Cytokine Signaling Proteins
0
cytokine inducible SH2-containing protein
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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