Twists and turns from "tumor in tumor" profiling: surveillance of chronic lymphocytic leukemia (CLL) leads to detection of a lung adenocarcinoma, whose genomic characterization alters the original hematologic diagnosis.
Adenocarcinoma of Lung
/ diagnosis
Aged
Biomarkers, Tumor
/ genetics
Diagnostic Errors
Female
Gene Expression Profiling
Gene Rearrangement
High-Throughput Nucleotide Sequencing
Humans
In Situ Hybridization, Fluorescence
Leukemia, Lymphocytic, Chronic, B-Cell
/ diagnosis
Lung Neoplasms
/ diagnosis
Lymphoma, Mantle-Cell
/ diagnosis
Neoplasms, Multiple Primary
/ diagnosis
Positron Emission Tomography Computed Tomography
chronic lymphatic leukemia
hematological neoplasm
lung adenocarcinoma
Journal
Cold Spring Harbor molecular case studies
ISSN: 2373-2873
Titre abrégé: Cold Spring Harb Mol Case Stud
Pays: United States
ID NLM: 101660017
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
22
02
2021
accepted:
03
05
2021
pubmed:
3
6
2021
medline:
5
1
2022
entrez:
2
6
2021
Statut:
epublish
Résumé
Comprehensive characterization of somatic genomic alterations has led to fundamental shifts in our understanding of tumor biology. In clinical practice, these studies can lead to modifications of diagnosis and/or specific treatment implications, fulfilling the promise of personalized medicine. Herein, we describe a 78-yr-old woman under surveillance for long-standing untreated chronic lymphocytic leukemia (CLL). Molecular studies from a peripheral blood specimen revealed a
Identifiants
pubmed: 34074652
pii: mcs.a006089
doi: 10.1101/mcs.a006089
pmc: PMC8327883
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Informations de copyright
© 2021 Terraf et al.; Published by Cold Spring Harbor Laboratory Press.
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