Cell-permeable lanthanide-platinum(IV) anti-cancer prodrugs.
Journal
Dalton transactions (Cambridge, England : 2003)
ISSN: 1477-9234
Titre abrégé: Dalton Trans
Pays: England
ID NLM: 101176026
Informations de publication
Date de publication:
29 Jun 2021
29 Jun 2021
Historique:
pubmed:
4
6
2021
medline:
15
12
2021
entrez:
3
6
2021
Statut:
ppublish
Résumé
Platinum compounds are a vital part of our anti-cancer arsenal, and determining the location and speciation of platinum compounds is crucial. We have synthesised a lanthanide complex bearing a salicylic group (Ln = Gd, Eu) which demonstrates excellent cellular accumulation and minimal cytotoxicity. Derivatisation enabled access to bimetallic lanthanide-platinum(ii) and lanthanide-platinum(iv) complexes. Luminescence from the europium-platinum(iv) system was quenched, and reduction to platinum(ii) with ascorbic acid resulted in a "switch-on" luminescence enhancement. We used diffusion-based 1H NMR spectroscopic methods to quantify cellular accumulation. The gadolinium-platinum(ii) and gadolinium-platinum(iv) complexes demonstrated appreciable cytotoxicity. A longer delay following incubation before cytotoxicity was observed for the gadolinium-platinum(iv) compared to the gadolinium-platinum(ii) complex. Functionalisation with octanoate ligands resulted in enhanced cellular accumulation and an even greater latency in cytotoxicity.
Identifiants
pubmed: 34080595
doi: 10.1039/d1dt01688a
pmc: PMC8237448
doi:
Substances chimiques
Coordination Complexes
0
Lanthanoid Series Elements
0
Prodrugs
0
Platinum
49DFR088MY
Gadolinium
AU0V1LM3JT
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
8761-8767Subventions
Organisme : Wellcome Trust
ID : 201406/Z/16/Z
Pays : United Kingdom
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