Sinapic acid reduces ischemia/reperfusion injury due to testicular torsion/detorsion in rats.
inflammation apoptosis
oxidative stress
sinapic acid
testicular torsion-detorsion
Journal
Andrologia
ISSN: 1439-0272
Titre abrégé: Andrologia
Pays: Germany
ID NLM: 0423506
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
revised:
23
04
2021
received:
06
03
2021
accepted:
28
04
2021
pubmed:
4
6
2021
medline:
12
8
2021
entrez:
3
6
2021
Statut:
ppublish
Résumé
This study aimed to investigate the protective effect of sinapic acid (SA) on biochemical and histopathological changes in an experimental testicular torsion-detorsion rat model. Twenty-four rats were randomised into four groups: sham group, ischemia/reperfusion (IR) group subjected to testicular torsion for 2 hr and then detorsion for 4 hr, and two groups treated with SA1 and SA2 (10 mg/kg and 20 mg/kg, by single intraperitoneal injection, 30 min before reperfusion). Serum testosterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) were measured by an autoanalyzer, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), malondialdehyde (MDA), protein carbonyl (PC), and nitric oxide (NO) oxidative stress parameters by spectrophotometric methods, and tumour necrosis factor (TNF-α), interleukin-1 beta (IL-1β), and interleukin 6 (IL-6) parameters by the Elisa method. In addition, immunohistochemical and histopathological examinations were performed on testicular tissues. There was no significant difference between the groups in terms of serum testosterone, FSH and LH levels (p > .05). SA significantly reduced increased testicular damage, oxidative stress, inflammation, cell death and also restored decreased antioxidant enzyme activities (p < .05). Pre-treatment of rats with SA reduced testicular dysfunction and morphological changes IRI. SA's antioxidant, anti-inflammatory, and antiapoptotic properties were found to be protective against testicular IR.
Substances chimiques
Coumaric Acids
0
Malondialdehyde
4Y8F71G49Q
sinapinic acid
68A28V6010
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14117Informations de copyright
© 2021 Wiley-VCH GmbH.
Références
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