Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy.
Amine Oxidase (Copper-Containing)
/ metabolism
Animals
Cattle
Cell Adhesion Molecules
/ metabolism
Crystallography, X-Ray
Deuterium
/ chemistry
Drug Design
Eye
/ metabolism
Fluorine
/ chemistry
Halogenation
Mice
Molecular Structure
Phenyl Ethers
/ chemical synthesis
Propanolamines
/ chemical synthesis
Protein Binding
Structure-Activity Relationship
cis-trans-Isomerases
/ metabolism
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
24 06 2021
24 06 2021
Historique:
pubmed:
4
6
2021
medline:
26
8
2021
entrez:
3
6
2021
Statut:
ppublish
Résumé
Recycling of all-
Identifiants
pubmed: 34081480
doi: 10.1021/acs.jmedchem.1c00279
pmc: PMC8381290
mid: NIHMS1732961
doi:
Substances chimiques
Cell Adhesion Molecules
0
Phenyl Ethers
0
Propanolamines
0
emixustat
02DZ1HBF0M
Fluorine
284SYP0193
Deuterium
AR09D82C7G
Amine Oxidase (Copper-Containing)
EC 1.4.3.21
semicarbazide-sensitive amine oxidase-vascular adhesion protein-1, mouse
EC 1.4.3.21
retinoid isomerohydrolase
EC 3.1.1.64
cis-trans-Isomerases
EC 5.2.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
8287-8302Subventions
Organisme : BLRD VA
ID : I01 BX004939
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY009339
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY030873
Pays : United States
Organisme : NEI NIH HHS
ID : R24 EY027283
Pays : United States
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