Genome-Based Discovery of Enantiomeric Pentacyclic Sesterterpenes Catalyzed by Fungal Bifunctional Terpene Synthases.

Alkyl and Aryl Transferases / chemistry Catalysis Cyclization Fungi / chemistry Molecular Structure Sesterterpenes / metabolism Stereoisomerism

Journal

Organic letters
ISSN: 1523-7052
Titre abrégé: Org Lett
Pays: United States
ID NLM: 100890393

Informations de publication

Date de publication:
18 06 2021
Historique:
pubmed: 5 6 2021
medline: 16 11 2021
entrez: 4 6 2021
Statut: ppublish

Résumé

Genome-based discovery of two previously unreported fungal bifunctional terpene synthases (BFTSs) from phytopathogenic fungi are reported: FoFS catalyzing the formation of fusoxypenes A-C (

Identifiants

DOI: 10.1021/acs.orglett.1c01361 PMID: 34085529
pubmed: 34085529
doi: 10.1021/acs.orglett.1c01361
doi:

Substances chimiques

Sesterterpenes 0
Alkyl and Aryl Transferases EC 2.5.-
terpene synthase EC 2.5.1.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4645-4650

Auteurs

Lan Jiang (L)

State Key Laboratory of Bioreactor Engineering, East China University of Science of Technology, Shanghai 200237, China.

Xue Zhang (X)

State Key Laboratory of Bioreactor Engineering, East China University of Science of Technology, Shanghai 200237, China.

Yuya Sato (Y)

Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan.

Guoliang Zhu (G)

State Key Laboratory of Bioreactor Engineering, East China University of Science of Technology, Shanghai 200237, China.

Atsushi Minami (A)

Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan.

Weiyan Zhang (W)

State Key Laboratory of Bioreactor Engineering, East China University of Science of Technology, Shanghai 200237, China.

Taro Ozaki (T)

Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan.
ORCID: 0000-0002-4673-4478

Bin Zhu (B)

State Key Laboratory of Bioreactor Engineering, East China University of Science of Technology, Shanghai 200237, China.
Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education, and Laboratory of Pharmaceutical Crystal Engineering & Technology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.

Zhixin Wang (Z)

State Key Laboratory of Bioreactor Engineering, East China University of Science of Technology, Shanghai 200237, China.

Xinye Wang (X)

State Key Laboratory of Bioreactor Engineering, East China University of Science of Technology, Shanghai 200237, China.

Kangjie Lv (K)

State Key Laboratory of Bioreactor Engineering, East China University of Science of Technology, Shanghai 200237, China.

Jingyu Zhang (J)

State Key Laboratory of Bioreactor Engineering, East China University of Science of Technology, Shanghai 200237, China.

Yongheng Wang (Y)

Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China.
ORCID: 0000-0002-2372-463X

Shushan Gao (S)

Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
ORCID: 0000-0001-6335-2052

Chengwei Liu (C)

Key Laboratory of Saline-Alkali Vegetation Ecology Restoration, Ministry of Education, College of Life Sciences, Northeast Forestry University, Harbin 150040, China.
ORCID: 0000-0003-2746-2080

Tom Hsiang (T)

School of Environmental Sciences, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1, Canada.

Lixin Zhang (L)

State Key Laboratory of Bioreactor Engineering, East China University of Science of Technology, Shanghai 200237, China.

Hideaki Oikawa (H)

Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan.
ORCID: 0000-0002-6947-3397

Xueting Liu (X)

State Key Laboratory of Bioreactor Engineering, East China University of Science of Technology, Shanghai 200237, China.
ORCID: 0000-0002-1322-8253

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Alkyl et aryl transferases › Genome-Based Discovery of Enantiomeric...
questionsmedicales.fr › Phénomènes chimiques › Catalyse › Genome-Based Discovery of Enantiomeric...
questionsmedicales.fr › Métabolisme › Cyclisation › Genome-Based Discovery of Enantiomeric...
questionsmedicales.fr › Eucaryotes › Champignons › Genome-Based Discovery of Enantiomeric...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Genome-Based Discovery of Enantiomeric...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Sesterterpènes › Genome-Based Discovery of Enantiomeric...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes de chimie organique › Isomérie › Stéréoisomérie › Genome-Based Discovery of Enantiomeric...