Generation and characterization of induced pluripotent stem cells heterozygous for the Portuguese BRCA2 founder mutation.
Journal
Stem cell research
ISSN: 1876-7753
Titre abrégé: Stem Cell Res
Pays: England
ID NLM: 101316957
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
18
02
2021
revised:
05
04
2021
accepted:
18
04
2021
entrez:
5
6
2021
pubmed:
6
6
2021
medline:
1
7
2021
Statut:
ppublish
Résumé
Women who inherit heterozygous mutations in the BRCA2 gene have an increased risk of developing cancer, mainly breast and ovarian tumors. A particular BRCA2 mutation (c.156_157insAlu) is exclusively found in families of Portuguese ancestry and is present in approximately 30% of all Portuguese families with hereditary breast and ovarian cancers. We report the generation and characterization of the first iPSC line from a female donor harboring the Portuguese BRCA2 founder mutation. Skin fibroblasts were reprogrammed using a non-integrative Sendai virus. These iPSCs are a valuable tool to study the origin of BRCA2-associated cancer in its earliest phases.
Identifiants
pubmed: 34087993
pii: S1873-5061(21)00210-5
doi: 10.1016/j.scr.2021.102364
pii:
doi:
Substances chimiques
BRCA2 Protein
0
BRCA2 protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102364Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.