Kiss1 is differentially regulated in male and female mice by the homeodomain transcription factor VAX1.
Animals
Arcuate Nucleus of Hypothalamus
/ metabolism
Cell Line
Female
Gene Deletion
Gene Expression Regulation
Gonadotropins
/ metabolism
Homeodomain Proteins
/ genetics
Humans
Hypothalamus, Anterior
/ metabolism
Kisspeptins
/ genetics
Male
Mice
Mice, Transgenic
Neuropeptides
/ genetics
Promoter Regions, Genetic
Sex Characteristics
Gene regulation
Hypothalamus
Kiss1
Kisspeptin
VAX1
Journal
Molecular and cellular endocrinology
ISSN: 1872-8057
Titre abrégé: Mol Cell Endocrinol
Pays: Ireland
ID NLM: 7500844
Informations de publication
Date de publication:
20 08 2021
20 08 2021
Historique:
received:
26
02
2021
revised:
13
05
2021
accepted:
01
06
2021
pubmed:
8
6
2021
medline:
12
1
2022
entrez:
7
6
2021
Statut:
ppublish
Résumé
Regulation of Kiss1 transcription is crucial to the development and function of the reproductive axis. The homeodomain transcription factor, ventral anterior homeobox 1 (VAX1), has been implicated as a potential regulator of Kiss1 transcription. However, it is unknown whether VAX1 directly mediates transcription within kisspeptin neurons or works indirectly by acting upstream of kisspeptin neuron populations. This study tested the hypothesis that VAX1 within kisspeptin neurons regulates Kiss1 gene expression. We found that VAX1 acts as a repressor of Kiss1 in vitro and within the male arcuate nucleus in vivo. In female mice, we found that the loss of VAX1 caused a reduction in Kiss1 expression and Kiss1-containing neurons in the anteroventral periventricular nucleus at the time of the preovulatory luteinizing hormone surge, but was compensated by an increase in Kiss1-cFos colocalization. Despite changes in Kiss1 transcription, gonadotropin levels were unaffected and there were no impairments to fertility.
Identifiants
pubmed: 34098016
pii: S0303-7207(21)00202-1
doi: 10.1016/j.mce.2021.111358
pmc: PMC8319105
mid: NIHMS1712990
pii:
doi:
Substances chimiques
Gonadotropins
0
Homeodomain Proteins
0
KISS1 protein, human
0
Kiss1 protein, mouse
0
Kisspeptins
0
Neuropeptides
0
Vax1 protein, mouse
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
111358Subventions
Organisme : NICHD NIH HHS
ID : R01 HD100580
Pays : United States
Organisme : NICHD NIH HHS
ID : R00 HD084759
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD007203
Pays : United States
Organisme : NIEHS NIH HHS
ID : P42 ES010337
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK063491
Pays : United States
Organisme : NICHD NIH HHS
ID : P50 HD028934
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA023100
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008666
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD072754
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD082567
Pays : United States
Organisme : NICHD NIH HHS
ID : K99 HD084759
Pays : United States
Organisme : NICHD NIH HHS
ID : F32 HD090837
Pays : United States
Organisme : NICHD NIH HHS
ID : P50 HD012303
Pays : United States
Organisme : NICHD NIH HHS
ID : R24 HD102061
Pays : United States
Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.
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