SARS-CoV-2 elicits robust adaptive immune responses regardless of disease severity.
Adaptive Immunity
Adult
Aged
Angiotensin-Converting Enzyme 2
/ metabolism
Animals
Antibodies, Neutralizing
/ blood
Antibodies, Viral
/ blood
CD8-Positive T-Lymphocytes
/ metabolism
COVID-19
/ immunology
Cell Line
Denmark
Female
Humans
Male
Middle Aged
SARS-CoV-2
/ immunology
Severity of Illness Index
Spike Glycoprotein, Coronavirus
/ immunology
Young Adult
Adaptive
Antibody
Asymptomatic
CD8(+) T-cell
COVID-19
Corona
Immune response
SARS-CoV-2
Severe
Virus
Journal
EBioMedicine
ISSN: 2352-3964
Titre abrégé: EBioMedicine
Pays: Netherlands
ID NLM: 101647039
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
04
03
2021
revised:
07
05
2021
accepted:
07
05
2021
pubmed:
8
6
2021
medline:
2
7
2021
entrez:
7
6
2021
Statut:
ppublish
Résumé
The SARS-CoV-2 pandemic currently prevails worldwide. To understand the immunological signature of SARS-CoV-2 infections and aid the search and evaluation of new treatment modalities and vaccines, comprehensive characterization of adaptive immune responses towards SARS-CoV-2 is needed. We included 203 recovered SARS-CoV-2 infected patients in Denmark between April 3 We report broad serological profiles within the cohort, detecting antibody binding to other human coronaviruses. 202(>99%) participants had SARS-CoV-2 specific antibodies, with SARS-CoV-2 neutralization and spike-ACE2 receptor interaction blocking observed in 193(95%) individuals. A significant positive correlation (r=0.7804) between spike-ACE2 blocking antibody titers and neutralization potency was observed. Further, SARS-CoV-2 specific CD8 The viral surface spike protein was identified as the dominant target for both neutralizing antibodies and CD8 This study was supported by the Danish Ministry for Research and Education (grant# 0238-00001B) and The Danish Innovation Fund (grant# 0208-00018B).
Sections du résumé
BACKGROUND
BACKGROUND
The SARS-CoV-2 pandemic currently prevails worldwide. To understand the immunological signature of SARS-CoV-2 infections and aid the search and evaluation of new treatment modalities and vaccines, comprehensive characterization of adaptive immune responses towards SARS-CoV-2 is needed.
METHODS
METHODS
We included 203 recovered SARS-CoV-2 infected patients in Denmark between April 3
FINDINGS
RESULTS
We report broad serological profiles within the cohort, detecting antibody binding to other human coronaviruses. 202(>99%) participants had SARS-CoV-2 specific antibodies, with SARS-CoV-2 neutralization and spike-ACE2 receptor interaction blocking observed in 193(95%) individuals. A significant positive correlation (r=0.7804) between spike-ACE2 blocking antibody titers and neutralization potency was observed. Further, SARS-CoV-2 specific CD8
INTERPRETATION
CONCLUSIONS
The viral surface spike protein was identified as the dominant target for both neutralizing antibodies and CD8
FUNDING
BACKGROUND
This study was supported by the Danish Ministry for Research and Education (grant# 0238-00001B) and The Danish Innovation Fund (grant# 0208-00018B).
Identifiants
pubmed: 34098342
pii: S2352-3964(21)00203-6
doi: 10.1016/j.ebiom.2021.103410
pmc: PMC8176920
pii:
doi:
Substances chimiques
Antibodies, Neutralizing
0
Antibodies, Viral
0
Spike Glycoprotein, Coronavirus
0
spike protein, SARS-CoV-2
0
ACE2 protein, human
EC 3.4.17.23
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
103410Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.