Salivary IgA antibody to malondialdehyde-acetaldehyde associates with mild periodontal pocket depth.
Acetaldehyde
/ metabolism
Aggregatibacter actinomycetemcomitans
Antigens, Bacterial
/ metabolism
Atherosclerosis
Chaperonin 60
/ metabolism
Epitopes
/ metabolism
Humans
Immunoglobulin A
/ metabolism
Immunoglobulin A, Secretory
/ metabolism
Malondialdehyde
/ metabolism
Periodontal Diseases
Periodontal Pocket
Porphyromonas gingivalis
/ metabolism
IgA
MAA
malondialdehyde-acetaldehyde
periodontal pocket depth
periodontitis
Journal
Oral diseases
ISSN: 1601-0825
Titre abrégé: Oral Dis
Pays: Denmark
ID NLM: 9508565
Informations de publication
Date de publication:
Nov 2022
Nov 2022
Historique:
revised:
03
05
2021
received:
15
10
2020
accepted:
30
05
2021
pubmed:
15
6
2021
medline:
12
10
2022
entrez:
14
6
2021
Statut:
ppublish
Résumé
Oxidized epitopes such as malondialdehyde-acetaldehyde (MAA) play a crucial role in the progression of atherosclerosis through activation of the humoral immune response. The exact mechanism of the association between atherosclerosis and periodontal diseases is not fully understood. The aim of the current study is to evaluate the association of oral humoral immune response to oxidized epitopes with parameters of periodontal disease. The Parogene cohort consist of patients who have undergone coronary angiography due to cardiac symptoms. In this study, 423 patients were randomly selected for an extensive oral examination. Salivary Immunoglobulin A to oxidized epitopes and bacterial antigens was determined by chemiluminescence immunoassay. In a binary logistic regression model adjusted with periodontal disease confounders, periodontal pocket depth (PPD) 4-5 mm associated with salivary IgA antibodies to MAA-LDL (p = 0.034), heat shock protein 60 of Aggregatibacter actinomycetemcomitans (p = 0.045), Porphyromonas gingivalis (p = 0.045), A. actinomycetemcomitans (p = 0.005), P. intermedia (p = 0.020), and total IgA (p = 0.003). The current study shows the association of salivary IgA to MAA-LDL with PPD 4-5 mm in a cohort of patients with chronic coronary artery disease. Humoral immune cross-reactivation to oxidized epitopes such MAA-LDL could partly explain the link of periodontitis with systemic diseases.
Substances chimiques
Antigens, Bacterial
0
Chaperonin 60
0
Epitopes
0
Immunoglobulin A
0
Immunoglobulin A, Secretory
0
Malondialdehyde
4Y8F71G49Q
Acetaldehyde
GO1N1ZPR3B
Types de publication
Journal Article
Langues
eng
Pagination
2285-2293Subventions
Organisme : University of Oulu Scholarship Foundation
Organisme : The Paulo foundation
Organisme : University of Oulu Graduate School
Organisme : Finnish Dental Society Apollonia
Organisme : The Päivikki and Sakari Sohlberg foundation
Organisme : The Sigrid Juselius foundation
Organisme : Academy of Finland
ID : 1266953
Informations de copyright
© 2021 The Authors. Oral Diseases published by Wiley Periodicals LLC.
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