Tuneable Hybrid Hydrogels via Complementary Self-Assembly of a Bioactive Peptide with a Robust Polysaccharide.

Biocompatible Materials Hydrogels Peptides Phenylalanine Polysaccharides
agarose biomaterials biomimicry self-assembling peptide tunable scaffolds

Journal

ACS biomaterials science & engineering
ISSN: 2373-9878
Titre abrégé: ACS Biomater Sci Eng
Pays: United States
ID NLM: 101654670

Informations de publication

Date de publication:
12 07 2021
Historique:
pubmed: 15 6 2021
medline: 3 8 2021
entrez: 14 6 2021
Statut: ppublish

Résumé

Synthetic materials designed for improved biomimicry of the extracellular matrix must contain fibrous, bioactive, and mechanical cues. Self-assembly of low molecular weight gelator (LMWG) peptides Fmoc-DIKVAV (Fmoc-aspartic acid-isoleucine-lysine-valine-alanine-valine) and Fmoc-FRGDF (Fmoc-phenylalanine-arginine-glycine-aspartic acid-phenylalanine) creates fibrous and bioactive hydrogels. Polysaccharides such as agarose are biocompatible, degradable, and non-toxic. Agarose and these Fmoc-peptides have both demonstrated efficacy

Identifiants

DOI: 10.1021/acsbiomaterials.1c00675 PMID: 34125518
pubmed: 34125518
doi: 10.1021/acsbiomaterials.1c00675
doi:

Substances chimiques

Biocompatible Materials 0
Hydrogels 0
Peptides 0
Polysaccharides 0
Phenylalanine 47E5O17Y3R

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3340-3350

Auteurs

Kate Firipis (K)

Biofab3D, Aikenhead Centre for Medical Discovery, St Vincent's Hospital Melbourne, Fitzroy, VIC 3065, Australia.
Biomedical and Electrical Engineering, School of Engineering, RMIT University, Melbourne, VIC 3000, Australia.
ORCID: 0000-0002-0534-4924

Mitchell Boyd-Moss (M)

Biofab3D, Aikenhead Centre for Medical Discovery, St Vincent's Hospital Melbourne, Fitzroy, VIC 3065, Australia.
Biomedical and Electrical Engineering, School of Engineering, RMIT University, Melbourne, VIC 3000, Australia.
Institute of Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Waurn Ponds, VIC 3216, Australia.

Benjamin Long (B)

Faculty of Science and Technology, Federation University, Mt. Helen, VIC 3350, Australia.
ORCID: 0000-0002-3248-8851

Chaitali Dekiwadia (C)

RMIT Microscopy and MicroAnalysis Facility (RMMF), RMIT University, Melbourne, Vic 3000, Australia.

William Hoskin (W)

Faculty of Science and Technology, Federation University, Mt. Helen, VIC 3350, Australia.

Elena Pirogova (E)

Biomedical and Electrical Engineering, School of Engineering, RMIT University, Melbourne, VIC 3000, Australia.

David R Nisbet (DR)

Laboratory of Advanced Biomaterials, The Australian National University, Acton, Canberra 2601, Australia.
ORCID: 0000-0002-1343-0769

Robert M I Kapsa (RMI)

Biofab3D, Aikenhead Centre for Medical Discovery, St Vincent's Hospital Melbourne, Fitzroy, VIC 3065, Australia.
Biomedical and Electrical Engineering, School of Engineering, RMIT University, Melbourne, VIC 3000, Australia.
ARC Centre of Excellence in Electromaterials Science, Department of Medicine, Melbourne University, St Vincent's Hospital Melbourne, Fitzroy, Victoria 3065, Australia.
Department of Medicine, St Vincent's Hospital Melbourne, University of Melbourne, Fitzroy, Vic 3065, Australia.

Anita F Quigley (AF)

Biofab3D, Aikenhead Centre for Medical Discovery, St Vincent's Hospital Melbourne, Fitzroy, VIC 3065, Australia.
Biomedical and Electrical Engineering, School of Engineering, RMIT University, Melbourne, VIC 3000, Australia.
ARC Centre of Excellence in Electromaterials Science, Department of Medicine, Melbourne University, St Vincent's Hospital Melbourne, Fitzroy, Victoria 3065, Australia.
Department of Medicine, St Vincent's Hospital Melbourne, University of Melbourne, Fitzroy, Vic 3065, Australia.

Richard J Williams (RJ)

Biofab3D, Aikenhead Centre for Medical Discovery, St Vincent's Hospital Melbourne, Fitzroy, VIC 3065, Australia.
Institute of Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Waurn Ponds, VIC 3216, Australia.
ORCID: 0000-0003-3831-8738

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Classifications MeSH

questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Matériaux biocompatibles › Tuneable Hybrid Hydrogels via Complementary...
questionsmedicales.fr › Préparations pharmaceutiques › Colloïdes › Gels › Hydrogels › Tuneable Hybrid Hydrogels via Complementary...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Tuneable Hybrid Hydrogels via Complementary...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés essentiels › Phénylalanine › Tuneable Hybrid Hydrogels via Complementary...
questionsmedicales.fr › Glucides › Polyosides › Tuneable Hybrid Hydrogels via Complementary...