Antithyroid Drug Treatment in Graves' Disease.
Antithyroid agents
Congenital abnormalities
Graves disease
Iodine
Pregnancy
Recurrence
Journal
Endocrinology and metabolism (Seoul, Korea)
ISSN: 2093-5978
Titre abrégé: Endocrinol Metab (Seoul)
Pays: Korea (South)
ID NLM: 101554139
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
21
04
2021
accepted:
10
05
2021
pubmed:
17
6
2021
medline:
15
3
2022
entrez:
16
6
2021
Statut:
ppublish
Résumé
Graves' disease is associated with thyrotropin (TSH) receptor stimulating antibody, for which there is no therapeutic agent. This disease is currently treated through inhibition of thyroid hormone synthesis or destruction of the thyroid gland. Recurrence after antithyroid drug (ATD) treatment is common. Recent studies have shown that the longer is the duration of use of ATD, the higher is the remission rate. Considering the relationship between clinical outcomes and iodine intake, recurrence of Graves' disease is more common in iodine-deficient areas than in iodine-sufficient areas. Iodine restriction in an iodine-excessive area does not improve the effectiveness of ATD or increase remission rates. Recently, Danish and Korean nationwide studies noted significantly higher prevalence of birth defects in newborns exposed to ATD during the first trimester compared to that of those who did not have such exposure. The prevalence of birth defects was lowest when propylthiouracil (PTU) was used and decreased by only 0.15% when methimazole was changed to PTU in the first trimester. Therefore, it is best not to use ATD in the first trimester or to change to PTU before pregnancy.
Identifiants
pubmed: 34130446
pii: EnM.2021.1070
doi: 10.3803/EnM.2021.1070
pmc: PMC8258321
doi:
Substances chimiques
Antithyroid Agents
0
Methimazole
554Z48XN5E
Propylthiouracil
721M9407IY
Thyrotropin
9002-71-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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