Next-generation sequencing in two cases of de novo acute basophilic leukaemia.
Aged
Antigens, CD34
/ genetics
Basophils
/ metabolism
DNA-Binding Proteins
/ genetics
Dioxygenases
/ genetics
High-Throughput Nucleotide Sequencing
Humans
Interleukin-3 Receptor alpha Subunit
/ genetics
Leukemia, Basophilic, Acute
/ genetics
Male
Middle Aged
Mutation
Nucleophosmin
/ genetics
Proto-Oncogene Proteins c-kit
/ genetics
Sequence Analysis, DNA
Tumor Suppressor Protein p53
/ genetics
acute basophilic leukaemia
gemtuzumab ozogamicin
next-generation sequencing
Journal
Journal of cellular and molecular medicine
ISSN: 1582-4934
Titre abrégé: J Cell Mol Med
Pays: England
ID NLM: 101083777
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
revised:
17
04
2021
received:
02
03
2021
pubmed:
17
6
2021
medline:
3
2
2022
entrez:
16
6
2021
Statut:
ppublish
Résumé
Acute basophilic leukaemia (ABL) is a rare subtype of acute myeloid leukaemia (AML); therefore, few data are available about its biology. Herein, we analysed two ABL patients using flow cytometry and next-generation sequencing (NGS). Two cell populations were detected by flow cytometry in both patients. In Case no. 1, blasts (CD34
Identifiants
pubmed: 34132463
doi: 10.1111/jcmm.16591
pmc: PMC8278069
doi:
Substances chimiques
Antigens, CD34
0
DNA-Binding Proteins
0
Interleukin-3 Receptor alpha Subunit
0
NPM1 protein, human
0
Tumor Suppressor Protein p53
0
Nucleophosmin
117896-08-9
Dioxygenases
EC 1.13.11.-
TET2 protein, human
EC 1.13.11.-
Proto-Oncogene Proteins c-kit
EC 2.7.10.1
Types de publication
Case Reports
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7095-7099Informations de copyright
© 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.
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