Genetic Evidence for a Potential Environmental Pathway to Spillover Infection of Rat-Borne Leptospirosis.
Leptospira interrogans
Rattus norvegicus
environmental reservoir
genotyping
leptospirosis
pathogenic Leptospira
soil
water
Journal
The Journal of infectious diseases
ISSN: 1537-6613
Titre abrégé: J Infect Dis
Pays: United States
ID NLM: 0413675
Informations de publication
Date de publication:
05 01 2022
05 01 2022
Historique:
received:
11
03
2021
accepted:
15
06
2021
pubmed:
18
6
2021
medline:
24
2
2022
entrez:
17
6
2021
Statut:
ppublish
Résumé
In this study, we genotyped samples from environmental reservoirs (surface water and soil), colonized rat specimens, and cases of human severe leptospirosis from an endemic urban slum in Brazil, to determine the molecular epidemiology of pathogenic Leptospira and identify pathways of leptospirosis infection. We identified a well-established population of Leptospira interrogans serovar Copenhageni common to human leptospirosis cases, and animal and environmental reservoirs. This finding provides genetic evidence for a potential environmental spillover pathway for rat-borne leptospirosis through the environment in this urban community and highlights the importance of environmental and social interventions to reduce spillover infections.
Identifiants
pubmed: 34139761
pii: 6303542
doi: 10.1093/infdis/jiab323
pmc: PMC8730487
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
130-134Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R01 AI121207
Pays : United States
Organisme : Wellcome Trust
ID : 102330/Z/13/Z
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R01 AI052473
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI088752
Pays : United States
Organisme : FIC NIH HHS
ID : R25 TW009338
Pays : United States
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
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