Disproportionation of Pharmaceutical Salts: pH

Drug Compounding / methods Drug Stability Excipients / chemistry Hydrogen-Ion Concentration Phenanthrenes / chemistry Sodium Chloride / chemistry Solubility Thermodynamics Water / chemistry
Gibbs buffer Gibbs pH disproportionation pH eutectic mixture mass action model multiphasic equilibria pH-dependent solubility pHmax pHmin phase-solubility salt disproportionation solubility product

Journal

Molecular pharmaceutics
ISSN: 1543-8392
Titre abrégé: Mol Pharm
Pays: United States
ID NLM: 101197791

Informations de publication

Date de publication:
05 07 2021
Historique:
pubmed: 19 6 2021
medline: 11 1 2022
entrez: 18 6 2021
Statut: ppublish

Résumé

A multiphasic mass action equilibrium model is used to show that the critical pH in the acid-base disproportionation of a solid salt into its corresponding solid free-base form in aqueous suspensions, widely known as "pH

Identifiants

DOI: 10.1021/acs.molpharmaceut.1c00258 PMID: 34142831
pubmed: 34142831
doi: 10.1021/acs.molpharmaceut.1c00258
doi:

Substances chimiques

Excipients 0
Phenanthrenes 0
Water 059QF0KO0R
alpha-(2-piperidyl)-3,6-bis(trifluoromethyl)-9-phenanthrenemethanol 31817-24-0
Sodium Chloride 451W47IQ8X

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

2724-2743

Auteurs

Alex Avdeef (A)

in-ADME Research, 1732 First Avenue #102, New York, New York 10128, United States.
ORCID: 0000-0002-3139-5442

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Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Préparation de médicament › Disproportionation of Pharmaceutical Salts: pH
questionsmedicales.fr › Techniques d'investigation › Stabilité de médicament › Disproportionation of Pharmaceutical Salts: pH
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Excipients pharmaceutiques › Excipients › Disproportionation of Pharmaceutical Salts: pH
questionsmedicales.fr › Phénomènes chimiques › Concentration en ions d'hydrogène › Disproportionation of Pharmaceutical Salts: pH
questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Phénanthrènes › Disproportionation of Pharmaceutical Salts: pH
questionsmedicales.fr › Produits chimiques inorganiques › Composés du sodium › Chlorure de sodium › Disproportionation of Pharmaceutical Salts: pH
questionsmedicales.fr › Phénomènes chimiques › Solubilité › Disproportionation of Pharmaceutical Salts: pH
questionsmedicales.fr › Phénomènes physiques › Thermodynamique › Disproportionation of Pharmaceutical Salts: pH
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Eau › Disproportionation of Pharmaceutical Salts: pH