Alex Avdeef

Affiliations

in-ADME Research, 1732 First Avenue #102, New York, New York 10128, United States.

ORCID: 0000-0002-3139-5442

Publications (24)

Disproportionation of Pharmaceutical Salts: pH

Molecular pharmaceutics

Avec: Alex Avdeef

Integration of In Silico, In Vitro and In Situ Tools for the Preformulation and Characterization of a Novel Cardio-Neuroprotective Compound during the Early Stages of Drug Development.

Pharmaceutics

Avec: Claudia Miranda , Alejandro Ruiz-Picazo , Paula Pomares , Isabel Gonzalez-Alvarez , Marival Bermejo , Marta Gonzalez-Alvarez , Alex Avdeef , Miguel-Ángel Cabrera-Pérez

Solubility-pH profile of desipramine hydrochloride in saline phosphate buffer: Enhanced solubility due to drug-buffer aggregates.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Avec: Olivera S Marković , Miloš P Pešić , Ankita V Shah , Abu T M Serajuddin , Tatjana Ž Verbić , Alex Avdeef

Is equilibrium slurry pH a good surrogate for solid surface pH during drug dissolution?

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Avec: Taiga Uekusa , Alex Avdeef , Kiyohiko Sugano

Understanding the pH Dependence of Supersaturation State-A Case Study of Telmisartan.

Pharmaceutics

Avec: Szabina Kádár , Dóra Csicsák , Petra Tőzsér , Attila Farkas , Tamás Pálla , Arash Mirzahosseini , Blanka Tóth , Gergő Tóth , Béla Fiser , Péter Horváth , János Madarász , Alex Avdeef , Krisztina Takács-Novák , Bálint Sinkó , Enikő Borbás , Gergely Völgyi

Clofazimine p

Molecular pharmaceutics

Avec: Tatjana Ž Verbić , Kin Y Tam , Dušan Ž Veljković , Abu T M Serajuddin , Alex Avdeef

Perspectives in solubility measurement and interpretation.

ADMET & DMPK

Avec: Christel A S Bergström , Alex Avdeef

Can small drugs predict the intrinsic aqueous solubility of 'beyond Rule of 5' big drugs?

ADMET & DMPK

Avec: Alex Avdeef , Manfred Kansy

Prediction of aqueous intrinsic solubility of druglike molecules using Random Forest regression trained with Wiki-pS0 database.

ADMET & DMPK

Avec: Alex Avdeef

A comparison of USP 2 and µDISS Profiler™ apparatus for studying dissolution phenomena of ibuprofen and its salts.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Avec: Laurin Zöller , Alex Avdeef , Eva Karlsson , Anders Borde , Sara Carlert , Christoph Saal , Jennifer Dressman

Supersolubilization and amorphization of a weakly acidic drug, Flurbiprofen, by applying Acid-Base supersolubilization (ABS) principle.

International journal of pharmaceutics

Avec: Mohammed I Syed , Hari P Kandagatla , Alex Avdeef , Abu T M Serajuddin

Solubility Challenge Revisited after Ten Years, with Multilab Shake-Flask Data, Using Tight (SD ∼ 0.17 log) and Loose (SD ∼ 0.62 log) Test Sets.

Journal of chemical information and modeling

Avec: Antonio Llinas , Alex Avdeef

"Flexible-Acceptor" General Solubility Equation for beyond Rule of 5 Drugs.

Molecular pharmaceutics

Avec: Alex Avdeef , Manfred Kansy

Potentiometric CheqSol and standardized shake-flask solubility methods are complimentary tools in physicochemical profiling.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Avec: Diego Lucero-Borja , Xavier Subirats , Rafael Barbas , Rafel Prohens , Alex Avdeef , Clara Ràfols

Ionizable Drug Self-Associations and the Solubility Dependence on pH: Detection of Aggregates in Saturated Solutions Using Mass Spectrometry (ESI-Q-TOF-MS/MS).

Molecular pharmaceutics

Avec: Elisabet Fuguet , Xavier Subirats , Clara Ràfols , Elisabeth Bosch , Alex Avdeef

Mechanistically transparent models for predicting aqueous solubility of rigid, slightly flexible, and very flexible drugs (MW<2000) Accuracy near that of random forest regression.

ADMET & DMPK

Avec: Alex Avdeef

Findings of the Second Challenge to Predict Aqueous Solubility.

Journal of chemical information and modeling

Avec: Antonio Llinas , Ioana Oprisiu , Alex Avdeef

The Critical Role of Passive Permeability in Designing Successful Drugs.

ChemMedChem

Avec: Li Di , Per Artursson , Alex Avdeef , Leslie Z Benet , J Brian Houston , Manfred Kansy , Edward H Kerns , Hans Lennernäs , Dennis A Smith , Kiyohiko Sugano

Salt Solubility and Disproportionation - Uses and Limitations of Equations for pH

Journal of pharmaceutical sciences

Avec: Alex Avdeef , Kiyohiko Sugano

Nortriptyline Hydrochloride Solubility-pH Profiles in a Saline Phosphate Buffer: Drug-Phosphate Complexes and Multiple pH

Molecular pharmaceutics

Avec: Olivera S Marković , Nirali G Patel , Abu T M Serajuddin , Alex Avdeef , Tatjana Ž Verbić

Predicting Solubility of Newly-Approved Drugs (2016-2020) with a Simple ABSOLV and GSE(

Journal of solution chemistry

Avec: Alex Avdeef , Manfred Kansy

Multi-lab intrinsic solubility measurement reproducibility in CheqSol and shake-flask methods.

ADMET & DMPK

Avec: Alex Avdeef

Do you know your r

ADMET & DMPK

Avec: Alex Avdeef

Anomalous salting-out, self-association and p

ADMET & DMPK

Avec: Alex Avdeef

Réseau de co-auteurs

Abu T M Serajuddin 4 collaborations

Manfred Kansy 4 collaborations

Tatjana Ž Verbić 3 collaborations

Kiyohiko Sugano 3 collaborations

Olivera S Marković 2 collaborations

Antonio Llinas 2 collaborations

Xavier Subirats 2 collaborations

Clara Ràfols 2 collaborations

Claudia Miranda 1 collaboration

Alejandro Ruiz-Picazo 1 collaboration

Paula Pomares 1 collaboration

Isabel Gonzalez-Alvarez 1 collaboration

Marival Bermejo 1 collaboration

Marta Gonzalez-Alvarez 1 collaboration

Miguel-Ángel Cabrera-Pérez 1 collaboration

Miloš P Pešić 1 collaboration

Ankita V Shah 1 collaboration

Taiga Uekusa 1 collaboration

Szabina Kádár 1 collaboration

Dóra Csicsák 1 collaboration

Petra Tőzsér 1 collaboration

Attila Farkas 1 collaboration

Tamás Pálla 1 collaboration

Arash Mirzahosseini 1 collaboration

Blanka Tóth 1 collaboration

Gergő Tóth 1 collaboration

Béla Fiser 1 collaboration

Péter Horváth 1 collaboration

János Madarász 1 collaboration

Krisztina Takács-Novák 1 collaboration

Bálint Sinkó 1 collaboration

Enikő Borbás 1 collaboration

Gergely Völgyi 1 collaboration

Kin Y Tam 1 collaboration

Dušan Ž Veljković 1 collaboration

Christel A S Bergström 1 collaboration

Laurin Zöller 1 collaboration

Eva Karlsson 1 collaboration

Anders Borde 1 collaboration

Sara Carlert 1 collaboration

Christoph Saal 1 collaboration

Jennifer Dressman 1 collaboration

Mohammed I Syed 1 collaboration

Hari P Kandagatla 1 collaboration

Diego Lucero-Borja 1 collaboration

Rafael Barbas 1 collaboration

Rafel Prohens 1 collaboration

Elisabet Fuguet 1 collaboration

Elisabeth Bosch 1 collaboration

Ioana Oprisiu 1 collaboration

Li Di 1 collaboration

Per Artursson 1 collaboration

Leslie Z Benet 1 collaboration

J Brian Houston 1 collaboration

Edward H Kerns 1 collaboration

Hans Lennernäs 1 collaboration

Dennis A Smith 1 collaboration

Nirali G Patel 1 collaboration