Clofazimine p
UV/vis spectrophotometry
clofazimine
density functional theory
dimerization
pKa value
potentiometry
principal component analysis
Journal
Molecular pharmaceutics
ISSN: 1543-8392
Titre abrégé: Mol Pharm
Pays: United States
ID NLM: 101197791
Informations de publication
Date de publication:
05 06 2023
05 06 2023
Historique:
medline:
6
6
2023
pubmed:
25
4
2023
entrez:
25
04
2023
Statut:
ppublish
Résumé
The weakly basic antibiotic and anti-inflammatory drug, clofazimine (CFZ), was first described in 1957. It has been used therapeutically, most notably in the treatment of leprosy. However, the compound is extremely insoluble in aqueous media, and, indeed, there is poor consensus about what its intrinsic solubility is since the reported values range from 0.04 to 11 ng/mL. To understand the speciation and solubilization of CFZ as a function of pH, it is of paramount importance to know the true aqueous p
Identifiants
pubmed: 37096898
doi: 10.1021/acs.molpharmaceut.3c00172
doi:
Substances chimiques
Methanol
Y4S76JWI15
Clofazimine
D959AE5USF
Water
059QF0KO0R
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM