Transmembrane dislocases: a second chance for protein targeting.
AAA-ATPase Msp1/ATAD1/Thorase
ER-associated degradation
P5-type ATPase Spf1/ATP13A1
mitochondrial protein quality control
protein homeostasis
protein quality control
Journal
Trends in cell biology
ISSN: 1879-3088
Titre abrégé: Trends Cell Biol
Pays: England
ID NLM: 9200566
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
17
03
2021
revised:
11
05
2021
accepted:
14
05
2021
pubmed:
21
6
2021
medline:
25
3
2022
entrez:
20
6
2021
Statut:
ppublish
Résumé
Precise distribution of proteins is essential to sustain the viability of cells. A complex network of protein synthesis and targeting factors cooperate with protein quality control systems to ensure protein homeostasis. Defective proteins are inevitably degraded by the ubiquitin-proteasome system and lysosomes. However, due to overlapping targeting information and limited targeting fidelity, certain proteins become mislocalized. In this review, we present the idea that transmembrane dislocases recognize and remove mislocalized membrane proteins from cellular organelles. This enables other targeting attempts and prevents degradation of mislocalized but otherwise functional proteins. These transmembrane dislocases can be found in the outer mitochondrial membrane (OMM) and endoplasmic reticulum (ER). We highlight common principles regarding client recognition and outline open questions in our understanding of transmembrane dislocases.
Identifiants
pubmed: 34147299
pii: S0962-8924(21)00099-4
doi: 10.1016/j.tcb.2021.05.007
pii:
doi:
Substances chimiques
Membrane Proteins
0
Proteasome Endopeptidase Complex
EC 3.4.25.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
898-911Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.