Outcomes associated with pacemaker implantation following transcatheter aortic valve replacement: A nationwide cohort study.
Aged, 80 and over
Aortic Valve Stenosis
/ surgery
Arrhythmias, Cardiac
/ epidemiology
Cardiac Pacing, Artificial
/ methods
Female
Follow-Up Studies
France
/ epidemiology
Heart Valve Prosthesis
/ adverse effects
Humans
Incidence
Male
Patient Readmission
Postoperative Complications
/ epidemiology
Retrospective Studies
Risk Factors
Transcatheter Aortic Valve Replacement
/ adverse effects
Aortic stenosis
Heart failure
Outcome
Pacemaker
Pacing-induced cardiomyopathy
Transcatheter aortic valve replacement
Journal
Heart rhythm
ISSN: 1556-3871
Titre abrégé: Heart Rhythm
Pays: United States
ID NLM: 101200317
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
16
03
2021
revised:
27
05
2021
accepted:
10
06
2021
pubmed:
21
6
2021
medline:
1
2
2022
entrez:
20
6
2021
Statut:
ppublish
Résumé
Conduction abnormalities following transcatheter aortic valve replacement (TAVR) often may require permanent pacemaker implantation (PPM). The purpose of this study was to evaluate outcomes associated with PPM after a TAVR procedure in a large, nationwide-level population. Based on the administrative hospital discharge database, the incidence of all-cause death, cardiovascular death, and hospitalization for heart failure (HF) were retrospectively collected, based on the presence or absence of PPM, in the first 30 days following all TAVRs in France from 2010 to 2019. Among 520,662 patients hospitalized for aortic stenosis, 49,201 were treated with TAVR. A total of 29,422 patients had follow-up ≥6 months (median 1.7 years), 22% already had PPM at baseline, and 22% underwent PPM within the first 30 days post-TAVR. Adjusted hazard ratios for the combined risk of all-cause death and hospitalization for HF, during the whole follow-up, were higher in both patients with a previous PPM and in those implanted within 30 days (hazard ratio [95% confidence interval] 1.12 [1.07-1.17] and 1.11 [1.06-1.16], respectively). PPM at baseline and within 30 days post-TAVR are independently associated with higher mortality and HF hospitalization during follow-up.
Sections du résumé
BACKGROUND
Conduction abnormalities following transcatheter aortic valve replacement (TAVR) often may require permanent pacemaker implantation (PPM).
OBJECTIVE
The purpose of this study was to evaluate outcomes associated with PPM after a TAVR procedure in a large, nationwide-level population.
METHODS
Based on the administrative hospital discharge database, the incidence of all-cause death, cardiovascular death, and hospitalization for heart failure (HF) were retrospectively collected, based on the presence or absence of PPM, in the first 30 days following all TAVRs in France from 2010 to 2019.
RESULTS
Among 520,662 patients hospitalized for aortic stenosis, 49,201 were treated with TAVR. A total of 29,422 patients had follow-up ≥6 months (median 1.7 years), 22% already had PPM at baseline, and 22% underwent PPM within the first 30 days post-TAVR. Adjusted hazard ratios for the combined risk of all-cause death and hospitalization for HF, during the whole follow-up, were higher in both patients with a previous PPM and in those implanted within 30 days (hazard ratio [95% confidence interval] 1.12 [1.07-1.17] and 1.11 [1.06-1.16], respectively).
CONCLUSION
PPM at baseline and within 30 days post-TAVR are independently associated with higher mortality and HF hospitalization during follow-up.
Identifiants
pubmed: 34147701
pii: S1547-5271(21)01730-6
doi: 10.1016/j.hrthm.2021.06.1175
pii:
doi:
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
2027-2032Informations de copyright
Copyright © 2021 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.