Lower White Matter Volume and Worse Executive Functioning Reflected in Higher Levels of Plasma GFAP among Older Adults with and Without Cognitive Impairment.
Aging
Alzheimer’s
Astrocyte
Biomarkers
Dementia
Glial fibrillary acidic protein
Journal
Journal of the International Neuropsychological Society : JINS
ISSN: 1469-7661
Titre abrégé: J Int Neuropsychol Soc
Pays: England
ID NLM: 9503760
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
pubmed:
24
6
2021
medline:
23
7
2022
entrez:
23
6
2021
Statut:
ppublish
Résumé
There are minimal data directly comparing plasma neurofilament light (NfL) and glial fibrillary acidic protein (GFAP) in aging and neurodegenerative disease research. We evaluated associations of plasma NfL and plasma GFAP with brain volume and cognition in two independent cohorts of older adults diagnosed as clinically normal (CN), mild cognitive impairment (MCI), or Alzheimer's dementia. We studied 121 total participants (Cohort 1: Higher plasma GFAP was associated with lower white matter volume in both cohorts for temporal (Cohort 1: Plasma GFAP may be more sensitive to white matter and cognitive changes than plasma NfL. Biomarkers reflecting astroglial pathophysiology may capture complex dynamics of aging and neurodegenerative disease.
Identifiants
pubmed: 34158138
pii: S1355617721000813
doi: 10.1017/S1355617721000813
pmc: PMC8692495
mid: NIHMS1707674
doi:
Substances chimiques
Biomarkers
0
Glial Fibrillary Acidic Protein
0
Neurofilament Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
588-599Subventions
Organisme : NIA NIH HHS
ID : K23 AG061253
Pays : United States
Organisme : NIA NIH HHS
ID : L30 AG069301
Pays : United States
Organisme : NIA NIH HHS
ID : K24 AG045333
Pays : United States
Organisme : NIA NIH HHS
ID : U24 AG021886
Pays : United States
Organisme : CSRD VA
ID : IK2 CX002180
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG063911
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG032289
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG062422
Pays : United States
Organisme : NIA NIH HHS
ID : K23 AG031861
Pays : United States
Organisme : NIA NIH HHS
ID : K23 AG059888
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG032289
Pays : United States
Organisme : NIA NIH HHS
ID : K23 AG073514
Pays : United States
Organisme : NINDS NIH HHS
ID : UF1 NS100608
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG048234
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG038791
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG019724
Pays : United States
Organisme : NIA NIH HHS
ID : K23 AG058752
Pays : United States
Organisme : NINDS NIH HHS
ID : U54 NS092089
Pays : United States
Organisme : NINDS NIH HHS
ID : UH3 NS100608
Pays : United States
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