Translating biased agonists from molecules to medications: Serotonin 5-HT
Behavior
Biased agonism
Brain imaging
Drug discovery
Serotonin 5-HT(1A) receptor
Signal transduction
Journal
Pharmacology & therapeutics
ISSN: 1879-016X
Titre abrégé: Pharmacol Ther
Pays: England
ID NLM: 7905840
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
received:
15
04
2021
revised:
01
06
2021
accepted:
17
06
2021
pubmed:
27
6
2021
medline:
19
3
2022
entrez:
26
6
2021
Statut:
ppublish
Résumé
Biased agonism (or "functional selectivity") at G-protein-coupled receptors has attracted rapidly increasing interest as a means to improve discovery of more efficacious and safer pharmacotherapeutics. However, most studies are limited to in vitro tests of cellular signaling and few biased agonists have progressed to in vivo testing. As concerns 5-HT
Identifiants
pubmed: 34174274
pii: S0163-7258(21)00139-X
doi: 10.1016/j.pharmthera.2021.107937
pii:
doi:
Substances chimiques
Serotonin 5-HT1 Receptor Agonists
0
Serotonin Receptor Agonists
0
Receptor, Serotonin, 5-HT1A
112692-38-3
Serotonin
333DO1RDJY
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
107937Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.