Antagonistic regulation controls clathrin-mediated endocytosis: AP2 adaptor facilitation vs restraint from clathrin light chains.
Clathrin adaptors
Clathrin-mediated endocytosis
Membrane biophysics
Membrane traffic
Protein self-assembly
Journal
Cells & development
ISSN: 2667-2901
Titre abrégé: Cells Dev
Pays: Netherlands
ID NLM: 101775611
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
17
03
2021
revised:
11
06
2021
accepted:
21
06
2021
pubmed:
29
6
2021
medline:
18
5
2022
entrez:
28
6
2021
Statut:
ppublish
Résumé
Orchestration of a complex network of protein interactions drives clathrin-mediated endocytosis (CME). A central role for the AP2 adaptor complex beyond cargo recognition and clathrin recruitment has emerged in recent years. It is now apparent that AP2 serves as a pivotal hub for protein interactions to mediate clathrin coated pit maturation, and couples lattice formation to membrane deformation. As a key driver for clathrin assembly, AP2 complements the attenuating role of clathrin light chain subunits, which enable dynamic lattice rearrangement needed for budding. This review summarises recent insights into AP2 function with respect to CME dynamics and biophysics, and its relationship to the role of clathrin light chains in clathrin assembly.
Identifiants
pubmed: 34182181
pii: S2667-2901(21)00048-6
doi: 10.1016/j.cdev.2021.203714
pii:
doi:
Substances chimiques
Adaptor Protein Complex 2
0
Clathrin
0
Clathrin Light Chains
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
203714Subventions
Organisme : Wellcome Trust
ID : 107858/Z/15/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 102394/Z/13/Z
Pays : United Kingdom
Informations de copyright
Copyright © 2021. Published by Elsevier B.V.