Activation of the hypothalamic-pituitary-adrenal axis by exogenous and endogenous GDF15.
Animals
Cisplatin
/ administration & dosage
Endoplasmic Reticulum Stress
/ drug effects
Glial Cell Line-Derived Neurotrophic Factor Receptors
/ metabolism
Glucocorticoids
/ metabolism
Growth Differentiation Factor 15
/ administration & dosage
Humans
Hypothalamo-Hypophyseal System
/ metabolism
Lipopolysaccharides
Mice
Pituitary-Adrenal System
/ metabolism
Rats
Tunicamycin
/ pharmacology
adrenal
corticosteroids
gdf15
stress
toxins
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
06 07 2021
06 07 2021
Historique:
entrez:
30
6
2021
pubmed:
1
7
2021
medline:
15
12
2021
Statut:
ppublish
Résumé
An acute increase in the circulating concentration of glucocorticoid hormones is essential for the survival of severe somatic stresses. Circulating concentrations of GDF15, a hormone that acts in the brain to reduce food intake, are frequently elevated in stressful states. We now report that GDF15 potently activates the hypothalamic-pituitary-adrenal (HPA) axis in mice and rats. A blocking antibody to the GDNF-family receptor α-like receptor completely prevented the corticosterone response to GDF15 administration. In wild-type mice exposed to a range of stressful stimuli, circulating levels of both corticosterone and GDF15 rose acutely. In the case of
Identifiants
pubmed: 34187898
pii: 2106868118
doi: 10.1073/pnas.2106868118
pmc: PMC8271778
pii:
doi:
Substances chimiques
GFRAL protein, mouse
0
Glial Cell Line-Derived Neurotrophic Factor Receptors
0
Glucocorticoids
0
Growth Differentiation Factor 15
0
Lipopolysaccharides
0
Tunicamycin
11089-65-9
Cisplatin
Q20Q21Q62J
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wellcome Trust
ID : WT 095515/Z/11/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N02995X/1
Pays : United Kingdom
Organisme : Department of Health
ID : CL-2019-14-504
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00014/5
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12012/1
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT 107064
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00014/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 220268/Z/20/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 100574/Z/12/Z
Pays : United Kingdom
Informations de copyright
Copyright © 2021 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
Competing interest statement: S.O. undertakes remunerated consultancy work for Pfizer, AstraZeneca, GSK. H.K., S.B.J., D.B., D.M.B., and K.K.B. are employed by Pfizer. S.B.J. and K.P. are employed at Novo Nordisk A/S, a pharmaceutical company, manufacturing and vending medicine. E.C.L. and H.L. are employed at and are shareholders of Kymab Ltd.
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