Allopregnanolone: An overview on its synthesis and effects.
neuroactive steroids
neurodegenerative disorders
progesterone metabolism
psychiatric disorders
sex difference
Journal
Journal of neuroendocrinology
ISSN: 1365-2826
Titre abrégé: J Neuroendocrinol
Pays: United States
ID NLM: 8913461
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
revised:
20
05
2021
received:
25
04
2021
accepted:
26
05
2021
pubmed:
1
7
2021
medline:
20
4
2022
entrez:
30
6
2021
Statut:
ppublish
Résumé
Allopregnanolone, a 3α,5α-progesterone metabolite, acts as a potent allosteric modulator of the γ-aminobutyric acid type A receptor. In the present review, the synthesis of this neuroactive steroid occurring in the nervous system is discussed with respect to physiological and pathological conditions. In addition, its physiological and neuroprotective effects are also reported. Interestingly, the levels of this neuroactive steroid, as well as its effects, are sex-dimorphic, suggesting a possible gender medicine based on this neuroactive steroid for neurological disorders. However, allopregnanolone presents low bioavailability and extensive hepatic metabolism, limiting its use as a drug. Therefore, synthetic analogues or a different therapeutic strategy able to increase allopregnanolone levels have been proposed to overcome any pharmacokinetic issues.
Identifiants
pubmed: 34189791
doi: 10.1111/jne.12996
pmc: PMC9285581
doi:
Substances chimiques
Neurosteroids
0
Progesterone
4G7DS2Q64Y
Pregnanolone
BXO86P3XXW
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12996Informations de copyright
© 2021 The Authors. Journal of Neuroendocrinology published by John Wiley & Sons Ltd on behalf of British Society for Neuroendocrinology.
Références
Neuropharmacology. 2021 Mar 15;186:108463
pubmed: 33460689
J Neuroendocrinol. 2011 Nov;23(11):961-73
pubmed: 21696472
Biol Psychiatry. 2006 Oct 1;60(7):704-13
pubmed: 16934764
Steroids. 2002 Apr;67(5):399-402
pubmed: 11958797
J Steroid Biochem Mol Biol. 2018 Apr;178:108-116
pubmed: 29183767
Neuropharmacology. 2011 Jun;60(7-8):1301-8
pubmed: 21256141
Psychopharmacology (Berl). 2016 Jun;233(11):2109-2117
pubmed: 26960697
Neuropsychopharmacology. 2018 May;43(6):1436-1444
pubmed: 29090684
J Peripher Nerv Syst. 2006 Jun;11(2):111-8
pubmed: 16787508
J Steroid Biochem. 1990 Jan;35(1):145-8
pubmed: 2308325
Biochim Biophys Acta Mol Basis Dis. 2017 Dec;1863(12):3016-3027
pubmed: 28899788
Neuroendocrinology. 2016;103(6):746-57
pubmed: 26646518
Acta Psychiatr Scand Suppl. 2000;(407):58-62
pubmed: 11261642
Horm Behav. 2008 Nov;54(5):726-34
pubmed: 18775724
Neuroscience. 2014 Jul 25;273:24-38
pubmed: 24814730
Ann N Y Acad Sci. 2004 Jun;1018:35-45
pubmed: 15240350
J Steroid Biochem Mol Biol. 2017 Nov;174:201-216
pubmed: 28951257
Nat Rev Drug Discov. 2010 Dec;9(12):971-88
pubmed: 21119734
Biol Psychiatry. 1997 Jul 15;42(2):104-15
pubmed: 9209727
J Psychopharmacol. 1996 Jan;10(4):266-72
pubmed: 22302972
Exp Clin Endocrinol. 1989;94(3):253-61
pubmed: 2630307
Drug Discov Today. 2003 May 15;8(10):445-50
pubmed: 12801796
J Neurosci. 2011 Dec 14;31(50):18198-210
pubmed: 22171026
Neuropharmacology. 2017 Apr;116:142-150
pubmed: 27986596
Psychopharmacology (Berl). 2014 Sep;231(17):3569-80
pubmed: 24781515
Exp Neurol. 2010 Nov;226(1):183-90
pubmed: 20816826
Br J Pharmacol. 2014 Dec;171(24):5870-80
pubmed: 25161074
Neural Regen Res. 2015 Jan;10(1):17-21
pubmed: 25788907
Int J Mol Sci. 2021 Feb 10;22(4):
pubmed: 33578758
Compr Psychiatry. 2008 May-Jun;49(3):238-46
pubmed: 18396182
Brain Res. 1991 Oct 4;561(1):157-61
pubmed: 1686744
Front Endocrinol (Lausanne). 2011 Oct 28;2:61
pubmed: 22654818
Neuropsychol Rehabil. 2007 Jun;17(3):293-313
pubmed: 17474058
Prog Neurobiol. 2003 Sep;71(1):67-80
pubmed: 14611869
Cell Metab. 2015 Apr 7;21(4):571-83
pubmed: 25817536
Ann Emerg Med. 2006 Apr;47(4):381-9
pubmed: 16546625
Adv Pharmacol. 2015;72:53-96
pubmed: 25600367
Behav Brain Res. 2020 Feb 3;379:112320
pubmed: 31669345
Psychoneuroendocrinology. 2019 Oct;108:53-61
pubmed: 31228750
Neuropharmacology. 2013 Aug;71:46-55
pubmed: 23542439
Front Neurosci. 2012 Feb 08;6:10
pubmed: 22347156
Cell Mol Life Sci. 2010 Sep;67(17):3017-34
pubmed: 20431905
Neuropharmacology. 2016 Dec;111:142-159
pubmed: 27596950
Am J Psychiatry. 1998 Oct;155(10):1358-64
pubmed: 9766767
J Steroid Biochem. 1988 Aug;31(2):173-9
pubmed: 3404987
J Steroid Biochem Mol Biol. 2008 Mar;109(1-2):96-107
pubmed: 18329265
Neurochem Int. 2010 Jan;56(1):118-27
pubmed: 19772882
Cell. 2010 Mar 19;140(6):918-34
pubmed: 20303880
Clin Neuropharmacol. 1996 Aug;19(4):366-9
pubmed: 8829001
JAMA. 1994 Dec 14;272(22):1763-9
pubmed: 7966925
Endocrinology. 2007 May;148(5):2505-17
pubmed: 17303653
Neurobiol Stress. 2019 Sep 27;11:100196
pubmed: 31649968
Psychol Med. 1999 Jul;29(4):769-86
pubmed: 10473304
J Endocrinol. 2020 Jan;244(1):201-211
pubmed: 31600724
Neurochem Int. 2012 May;60(6):616-21
pubmed: 22406419
Physiol Behav. 2008 Apr 22;94(1):121-35
pubmed: 18164737
J Neuroendocrinol. 2018 Feb;30(2):
pubmed: 29265686
Epilepsia. 2019 Apr;60(4):730-743
pubmed: 30895610
Prog Neurobiol. 2014 Feb;113:88-94
pubmed: 23978486
Cell. 2010 Jul 23;142(2):196-8
pubmed: 20655462
Lancet Psychiatry. 2019 Dec;6(12):975-977
pubmed: 31680013
Psychopharmacology (Berl). 2017 Sep;234(18):2793-2811
pubmed: 28664280
Exp Neurol. 2004 Oct;189(2):404-12
pubmed: 15380490
Biol Reprod. 1980 Mar;22(2):217-22
pubmed: 6991016
Lancet. 2018 Sep 22;392(10152):1058-1070
pubmed: 30177236
J Neuroendocrinol. 2019 Jun;31(6):e12736
pubmed: 31102564
J Neurochem. 2016 Dec;139(5):782-794
pubmed: 27256158
Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14602-7
pubmed: 16984997
Neuropharmacology. 2011 Sep;61(4):724-9
pubmed: 21640735
Proc Natl Acad Sci U S A. 1991 May 15;88(10):4553-7
pubmed: 1852011
Psychoneuroendocrinology. 2003 Apr;28 Suppl 2:83-96
pubmed: 12650683
Arch Gen Psychiatry. 2002 Feb;59(2):154-64
pubmed: 11825137
Nat Med. 2004 Jul;10(7):704-11
pubmed: 15208706
J Biol Chem. 1992 Sep 25;267(27):19548-54
pubmed: 1527072
Neurosci Lett. 2007 Sep 25;425(2):94-8
pubmed: 17826908
J Steroid Biochem Mol Biol. 2017 Jul;171:229-235
pubmed: 28408350
Nat Rev Neurosci. 2005 Jul;6(7):565-75
pubmed: 15959466
CNS Neurosci Ther. 2020 Feb;26(2):240-250
pubmed: 31332963
Dev Neurobiol. 2007 Mar;67(4):510-20
pubmed: 17443805
Neuroscience. 2005;135(1):47-58
pubmed: 16054770
J Neurosci Res. 1999 May 15;56(4):349-57
pubmed: 10340743
J Steroid Biochem Mol Biol. 1990 Nov 20;37(3):395-403
pubmed: 2257243
J Physiol. 1999 Dec 1;521 Pt 2:437-49
pubmed: 10581314
Brain Res Dev Brain Res. 2001 Nov 26;131(1-2):31-9
pubmed: 11718833
Neuroscience. 2011 Sep 15;191:101-6
pubmed: 21497181
Prog Neurobiol. 2010 Aug;91(4):362-75
pubmed: 20441786
Arch Gen Psychiatry. 1990 Jan;47(1):35-44
pubmed: 2294854
Brain Res. 2009 Aug 4;1283:177-85
pubmed: 19497309
J Neuroendocrinol. 2022 Feb;34(2):e12996
pubmed: 34189791
Prog Neurobiol. 2014 Feb;113:56-69
pubmed: 23958466
Int J Mol Sci. 2020 Oct 20;21(20):
pubmed: 33092287
Cell. 2016 Nov 3;167(4):915-932
pubmed: 27814521
Neuroendocrinology. 1986;42(1):6-14
pubmed: 3941760
PLoS One. 2015 Jun 03;10(6):e0128313
pubmed: 26039057
PLoS One. 2012;7(11):e50040
pubmed: 23209637
J Neurosci. 2005 May 25;25(21):5117-26
pubmed: 15917452
Endocrinology. 2008 Jun;149(6):2739-42
pubmed: 18308840
Brain Res Brain Res Rev. 2001 Nov;37(1-3):360-71
pubmed: 11744100
Endocrinology. 2007 May;148(5):2148-56
pubmed: 17289849
Physiol Behav. 1995 Nov;58(5):985-93
pubmed: 8577898
Singapore Med J. 2007 May;48(5):385-91
pubmed: 17453094
Cells. 2021 Mar 21;10(3):
pubmed: 33801063
CNS Drug Rev. 2006 Spring;12(1):53-76
pubmed: 16834758
Neuroscientist. 2010 Aug;16(4):408-20
pubmed: 20817918
Biol Sex Differ. 2018 Jan 19;9(1):6
pubmed: 29351809
J Neurochem. 2010 Feb;112(4):980-90
pubmed: 19943853
Histochem J. 1998 Oct;30(10):731-9
pubmed: 9874000
Psychoneuroendocrinology. 2013 Oct;38(10):2278-90
pubmed: 23706961
Front Cell Neurosci. 2014 Sep 11;8:256
pubmed: 25309317
Psychoneuroendocrinology. 2008 Jul;33(6):728-40
pubmed: 18396377
Pharmacol Rep. 2010 Nov-Dec;62(6):1030-40
pubmed: 21273660
Trends Pharmacol Sci. 2016 Jul;37(7):543-561
pubmed: 27156439
Behav Brain Res. 2016 May 15;305:258-64
pubmed: 26970579
Brain. 2011 Sep;134(Pt 9):2703-21
pubmed: 21908875
J Comp Neurol. 1999 Aug 23;411(2):267-73
pubmed: 10404252
Prog Brain Res. 2010;181:193-207
pubmed: 20478439
J Steroid Biochem Mol Biol. 2007 Nov-Dec;107(3-5):228-37
pubmed: 17692515
Neuropharmacology. 2015 Jan;88:63-73
pubmed: 25278033
Psychoneuroendocrinology. 2021 Jan;123:105039
pubmed: 33161257
Neurotherapeutics. 2021 Jan;18(1):544-555
pubmed: 33405197
Behav Brain Res. 2013 Mar 15;241:96-104
pubmed: 23228522
J Neurosci. 2009 May 20;29(20):6449-60
pubmed: 19458216
Prog Neurobiol. 2014 Feb;113:6-39
pubmed: 24172649
Behav Brain Res. 2008 Nov 21;193(2):269-76
pubmed: 18590775
Endocrinology. 2005 Mar;146(3):1626-37
pubmed: 15591137
J Neurogenet. 1996 Dec;11(1-2):45-58
pubmed: 10876649
Brain Pathol. 2010 Sep;20(5):945-51
pubmed: 20406233
Nat Rev Endocrinol. 2013 Apr;9(4):241-50
pubmed: 23438839
J Biol Chem. 1997 Dec 19;272(51):32129-35
pubmed: 9405411
J Neurosci Res. 2005 Dec 15;82(6):811-21
pubmed: 16273542
Epilepsy Behav. 2017 Mar;68:22-30
pubmed: 28109985
Neurotherapeutics. 2017 Oct;14(4):1073-1083
pubmed: 28707277
J Neurobiol. 1993 Jul;24(7):913-24
pubmed: 8228969
Alcohol Clin Exp Res. 2017 Feb;41(2):299-311
pubmed: 28068457
Pain. 2010 Sep;150(3):522-534
pubmed: 20605070
Drugs Today (Barc). 2019 Sep;55(9):537-544
pubmed: 31584571
Neurobiol Dis. 2010 Mar;37(3):510-8
pubmed: 19913097
Neuroscience. 2019 Jan 15;397:127-137
pubmed: 30513375
Ann Med. 1999 Dec;31(6):372-9
pubmed: 10680851
J Steroid Biochem Mol Biol. 2017 Mar;167:135-143
pubmed: 27890531
Horm Behav. 2006 Nov;50(4):612-22
pubmed: 16876167
Neurotherapeutics. 2020 Jan;17(1):178-188
pubmed: 31664643
Front Cell Neurosci. 2012 Dec 18;6:40
pubmed: 23264760
Mol Autism. 2015 Jun 05;6:33
pubmed: 26052415
Arch Gen Psychiatry. 1997 May;54(5):433-40
pubmed: 9152097
Neurobiol Stress. 2019 Dec 26;12:100209
pubmed: 32435662
Mol Biol Cell. 2000 Jul;11(7):2283-95
pubmed: 10888668
J Cell Physiol. 2012 Apr;227(4):1740-51
pubmed: 21688266
Front Pharmacol. 2021 Jan 14;11:608887
pubmed: 33519475
Front Neurosci. 2021 Jan 14;14:616298
pubmed: 33519367
Eur J Pharmacol. 2005 Apr 4;512(1):15-21
pubmed: 15814085
Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10978-83
pubmed: 9724815
Psychiatry Res. 2019 Sep;279:83-89
pubmed: 31323375
Br J Psychiatry. 2004 Jul;185:5-10
pubmed: 15231549
J Neurobiol. 2006 Aug;66(9):916-28
pubmed: 16758493
Exp Neurol. 2013 Nov;249:49-58
pubmed: 23928325
Behav Pharmacol. 2010 Feb;21(1):21-8
pubmed: 20009921
J Neurol. 2020 Sep;267(9):2507-2523
pubmed: 31041582
Prog Neurobiol. 2014 Feb;113:40-55
pubmed: 24044981
Annu Rev Biochem. 1994;63:25-61
pubmed: 7979239
Front Endocrinol (Lausanne). 2011 Dec 27;2:104
pubmed: 22654839
Sci Rep. 2016 Nov 25;6:37345
pubmed: 27886206
Behav Brain Res. 2017 Sep 15;334:6-15
pubmed: 28743598
Front Cell Neurosci. 2014 Jun 03;8:134
pubmed: 24917787
Neuroscience. 2006;138(3):809-19
pubmed: 16457952
Sci Rep. 2019 Feb 4;9(1):1220
pubmed: 30718548
Eur J Pharmacol. 1989 Jul 18;166(2):325-9
pubmed: 2792198
Psychoneuroendocrinology. 2000 May;25(4):407-20
pubmed: 10725616
Neurology. 1999 Dec 10;53(9):1992-7
pubmed: 10599770
Proc Natl Acad Sci U S A. 2005 Jun 21;102(25):9044-9
pubmed: 15951421
Brain Res. 2002 Apr 5;932(1-2):135-9
pubmed: 11911871
Int Rev Neurobiol. 2001;46:243-72
pubmed: 11599302
Brain Res Dev Brain Res. 1988 Dec 1;44(2):181-8
pubmed: 3224423
Behav Brain Res. 2021 Mar 5;401:113092
pubmed: 33359844
Steroids. 1999 Jan-Feb;64(1-2):83-91
pubmed: 10323676
Am J Psychiatry. 1999 Apr;156(4):603-9
pubmed: 10200741
Pharmacol Biochem Behav. 2000 Oct;67(2):345-53
pubmed: 11124400
Brain Behav Immun. 2016 Jul;55:202-214
pubmed: 26774528
Ann N Y Acad Sci. 2003 Dec;1007:335-9
pubmed: 14993066
PLoS One. 2014 Jul 02;9(7):e101450
pubmed: 24988461
Front Neuroendocrinol. 2009 Jul;30(2):142-57
pubmed: 19410597
Proc Natl Acad Sci U S A. 2014 May 13;111(19):7132-7
pubmed: 24778259
Neuropharmacology. 2015 Oct;97:86-94
pubmed: 26006269
Front Endocrinol (Lausanne). 2011 Aug 11;2:19
pubmed: 22649366
Microorganisms. 2017 Oct 12;5(4):
pubmed: 29023380
Rev Endocr Metab Disord. 2015 Sep;16(3):177-98
pubmed: 26296373
J Steroid Biochem Mol Biol. 2011 May;125(1-2):46-56
pubmed: 21272640
Biol Psychiatry. 2007 Apr 15;61(8):935-45
pubmed: 17046727
Neuroscience. 2015 Apr 2;290:138-46
pubmed: 25617652
Alcohol Clin Exp Res. 2011 May;35(5):946-52
pubmed: 21323680
J Neuroendocrinol. 2018 Feb;30(2):
pubmed: 29072794
Prog Neurobiol. 2014 Feb;113:95-105
pubmed: 23958467
Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jan 3;48:64-78
pubmed: 24044974
Pain. 2005 Oct;117(3):326-339
pubmed: 16150542
Cell Mol Neurobiol. 2002 Aug;22(4):445-54
pubmed: 12507393
Biol Psychiatry. 2003 Apr 1;53(7):593-600
pubmed: 12679237
Front Neuroendocrinol. 1992 Apr;13(2):163-215
pubmed: 1468601
Nat Rev Neurosci. 2011 Jul 13;12(8):453-66
pubmed: 21750565
Front Cell Neurosci. 2014 Jul 30;8:203
pubmed: 25126056
Neurosci Lett. 1998 Sep 4;253(2):111-4
pubmed: 9774162
Biol Psychiatry. 2004 Mar 1;55(5):512-7
pubmed: 15023579
Drug Alcohol Depend. 2010 Mar 1;107(2-3):264-7
pubmed: 20005642
J Affect Disord. 2003 Dec;77(3):197-202
pubmed: 14612219
Neuropharmacology. 2008 Feb;54(2):365-74
pubmed: 18045626
Neuroendocrinology. 2021;111(6):536-541
pubmed: 32492675
J Neurotrauma. 2005 Jan;22(1):106-18
pubmed: 15665606
J Am Acad Dermatol. 1998 Oct;39(4 Pt 1):578-89
pubmed: 9777765
EMBO Mol Med. 2013 Jun;5(6):891-903
pubmed: 23681668
Neurobiol Dis. 2010 Mar;37(3):491-2
pubmed: 20005951
Synapse. 2001 Aug;41(2):131-8
pubmed: 11400179
Neuropharmacology. 2005 Jan;48(1):14-24
pubmed: 15617723
Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10459-64
pubmed: 9724725
Neuroscience. 2013 Nov 12;252:201-11
pubmed: 23948640
Cell Mol Life Sci. 2008 Mar;65(5):777-97
pubmed: 18038216
Psychopharmacology (Berl). 2006 May;185(4):423-32
pubmed: 16544163
Diabetes Metab Res Rev. 2012 Jan;28(1):76-83
pubmed: 21695767
J Neurosci. 2010 Sep 8;30(36):11896-901
pubmed: 20826654
Brain Res. 1990 May 21;516(2):229-36
pubmed: 2364289
Pharmacol Ther. 2011 Oct;132(1):96-110
pubmed: 21704074
Pain. 2005 Apr;114(3):429-443
pubmed: 15777868
Chronic Stress (Thousand Oaks). 2019 Jan 1;3:
pubmed: 31276078
Front Behav Neurosci. 2019 Jun 11;13:114
pubmed: 31244621
Front Cell Neurosci. 2014 Aug 12;8:224
pubmed: 25161608
Brain Res Rev. 2008 Mar;57(2):398-409
pubmed: 17931704
Cerebellum. 2012 Jun;11(2):414-5
pubmed: 22198872
Schizophr Bull. 2001;27(1):103-13
pubmed: 11215540
Cell Mol Life Sci. 2020 Nov;77(22):4505-4522
pubmed: 32424438
J Neurosci. 2003 Nov 26;23(34):10934-43
pubmed: 14645489
J Steroid Biochem Mol Biol. 2003 Jun;85(2-5):247-55
pubmed: 12943710
Cell Mol Neurobiol. 2019 May;39(4):523-537
pubmed: 30187261
Int J Mol Sci. 2020 Dec 10;21(24):
pubmed: 33321734
Psychoneuroendocrinology. 2003 Apr;28 Suppl 2:17-54
pubmed: 12650680
J Autism Dev Disord. 2003 Aug;33(4):365-82
pubmed: 12959416
Prog Neurobiol. 2010 Sep;92(1):33-41
pubmed: 20438798
Neurochem Res. 2008 Aug;33(8):1568-73
pubmed: 18363096
J Neurochem. 2003 Aug;86(4):848-59
pubmed: 12887683
Front Endocrinol (Lausanne). 2011 Dec 02;2:90
pubmed: 22654832
Prog Neurobiol. 2003 Sep;71(1):57-66
pubmed: 14611868
Neurosci Bull. 2016 Aug;32(4):311-22
pubmed: 27325509
Mol Neurobiol. 2019 May;56(5):3702-3713
pubmed: 30187385
J Steroid Biochem Mol Biol. 2020 Oct;203:105732
pubmed: 32777355
J Pharmacol Exp Ther. 1997 Mar;280(3):1284-95
pubmed: 9067315
Pain. 2011 Jan;152(1):170-181
pubmed: 21071147
J Steroid Biochem Mol Biol. 2014 Jan;139:98-103
pubmed: 24176764
Neuroscience. 2009 Dec 1;164(2):520-9
pubmed: 19665520
Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2849-54
pubmed: 11226329
J Neurosci. 2015 Jan 14;35(2):666-77
pubmed: 25589761
Horm Behav. 2010 Jan;57(1):46-55
pubmed: 19422828
Prog Neurobiol. 2003 Sep;71(1):49-56
pubmed: 14611867
Curr Pharm Des. 2018;24(17):1839-1844
pubmed: 29766792
Psychoneuroendocrinology. 2017 May;79:116-121
pubmed: 28278440
Psychopharmacology (Berl). 2002 May;161(2):120-8
pubmed: 11981591
Front Cell Neurosci. 2019 Mar 08;13:83
pubmed: 30906252
Neurobiol Aging. 2003 Oct;24(6):853-60
pubmed: 12927767
Depress Anxiety. 2004;20(3):123-30
pubmed: 15487017
Prog Neurobiol. 2014 Feb;113:79-87
pubmed: 24215796
Endocrinology. 2016 Oct;157(10):3983-3993
pubmed: 27547849
J Physiol. 1998 Apr 1;508 ( Pt 1):289-300
pubmed: 9490853
Brain Behav Evol. 2010;76(3-4):279-88
pubmed: 21116109
Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14439-44
pubmed: 14623958
Neuroscience. 2008 Aug 26;155(3):673-85
pubmed: 18625290
Brain Res Rev. 2008 Mar;57(2):410-20
pubmed: 17629950
Epilepsia. 2020 Sep;61(9):e129-e134
pubmed: 32929741
Biol Psychiatry. 1999 Feb 1;45(3):274-7
pubmed: 10023501
Int Rev Neurobiol. 2001;46:145-76
pubmed: 11599299
Psychoneuroendocrinology. 2003 Apr;28 Suppl 2:1-16
pubmed: 12650679
Neuroscience. 1994 Sep;62(1):265-71
pubmed: 7816204
Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13284-9
pubmed: 9789080
Horm Behav. 2010 Jan;57(1):2-11
pubmed: 19524584
J Biol Chem. 2001 Jun 22;276(25):22278-86
pubmed: 11294878
J Neuroendocrinol. 2010 Nov;22(11):1137-47
pubmed: 20819120
Sci Rep. 2017 Jun 13;7(1):3348
pubmed: 28611376
Brain Res Brain Res Rev. 2005 Apr;48(2):328-38
pubmed: 15850671
J Pharmacol Exp Ther. 2018 Jun;365(3):583-601
pubmed: 29602830
Psychoneuroendocrinology. 2015 Jun;56:1-11
pubmed: 25770855
J Neurochem. 2014 Aug;130(4):591-7
pubmed: 24766130
Endocrinology. 1993 Mar;132(3):1252-9
pubmed: 8440186
Neuroscience. 2007 Feb 23;144(4):1293-304
pubmed: 17187935
Neurol Res. 2007 Sep;29(6):622-7
pubmed: 17535560
J Neurosci. 2002 May 1;22(9):3366-75
pubmed: 11978813
Eur J Neurosci. 2006 Nov;24(9):2567-74
pubmed: 17100844
J Anesth. 2011 Dec;25(6):942-5
pubmed: 21879341
Psychoneuroendocrinology. 2013 Feb;38(2):281-93
pubmed: 22776423
J Neurosurg. 2000 Oct;93(4):539-45
pubmed: 11014529
Am J Psychiatry. 1998 Jul;155(7):910-3
pubmed: 9659856
Front Neuroendocrinol. 2019 Oct;55:100795
pubmed: 31562849
Brain Res. 2009 May 13;1270:140-51
pubmed: 19328188
Brain Res Brain Res Rev. 2001 Nov;37(1-3):110-5
pubmed: 11744079
Curr Opin Neurobiol. 2020 Jun;62:26-33
pubmed: 31809998
Pediatr Res. 2019 Jan;85(1):86-96
pubmed: 30237570
J Neuroendocrinol. 2020 Jan;32(1):e12754
pubmed: 31175669
J Pharmacol Exp Ther. 2019 Mar;368(3):326-337
pubmed: 30552296
Brain Res. 1994 Mar 14;639(2):202-6
pubmed: 8205473
Neuropharmacology. 2002 Sep;43(4):651-61
pubmed: 12367610
Neurology. 1997 Jan;48(1):132-8
pubmed: 9008508
J Neuroendocrinol. 2012 Jun;24(6):851-61
pubmed: 22283602
J Neurochem. 2010 Aug;114(3):921-32
pubmed: 20492360
Pharmacol Biochem Behav. 2010 Jan;94(3):416-22
pubmed: 19840816
Glia. 1994 Jan;10(1):59-69
pubmed: 8300192
Pharmacol Rev. 2008 Sep;60(3):243-60
pubmed: 18790874
Physiol Behav. 1989 Sep;46(3):435-8
pubmed: 2623066
J Steroid Biochem Mol Biol. 2017 Nov;174:242-256
pubmed: 28982631
J Comp Neurol. 2004 Sep 20;477(3):286-99
pubmed: 15305365
Glia. 2001 Dec;36(3):295-308
pubmed: 11746767
J Mol Neurosci. 2007;31(2):149-57
pubmed: 17478888
Alzheimers Dement (N Y). 2020 Dec 16;6(1):e12107
pubmed: 33344752
Prog Neurobiol. 2014 Feb;113:70-8
pubmed: 23948490
J Neurochem. 2017 Aug;142(3):420-428
pubmed: 28467654
Epilepsia. 2018 Oct;59 Suppl 2:220-227
pubmed: 29453777
Transl Psychiatry. 2021 Feb 26;11(1):145
pubmed: 33637705
J Steroid Biochem Mol Biol. 2016 May;159:1-7
pubmed: 26892094
Neurochem Int. 2018 Sep;118:96-104
pubmed: 29859230