Structure and function of capsid protein in flavivirus infection and its applications in the development of vaccines and therapeutics.
Flavivirus
capsid protein
ecapsidation
therapeutic
vaccine
Journal
Veterinary research
ISSN: 1297-9716
Titre abrégé: Vet Res
Pays: England
ID NLM: 9309551
Informations de publication
Date de publication:
30 Jun 2021
30 Jun 2021
Historique:
received:
23
02
2021
accepted:
27
05
2021
entrez:
1
7
2021
pubmed:
2
7
2021
medline:
12
10
2021
Statut:
epublish
Résumé
Flaviviruses are enveloped single positive-stranded RNA viruses. The capsid (C), a structural protein of flavivirus, is dimeric and alpha-helical, with several special structural and functional features. The functions of the C protein go far beyond a structural role in virions. It is not only responsible for encapsidation to protect the viral RNA but also able to interact with various host proteins to promote virus proliferation. Therefore, the C protein plays an important role in infected host cells and the viral life cycle. Flaviviruses have been shown to affect the health of humans and animals. Thus, there is an urgent need to effectively control flavivirus infections. The structure of the flavivirus virion has been determined, but there is relatively little information about the function of the C protein. Hence, a greater understanding of the role of the C protein in viral infections will help to discover novel antiviral strategies and provide a promising starting point for the further development of flavivirus vaccines or therapeutics.
Identifiants
pubmed: 34193256
doi: 10.1186/s13567-021-00966-2
pii: 10.1186/s13567-021-00966-2
pmc: PMC8247181
doi:
Substances chimiques
Capsid Proteins
0
Viral Vaccines
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
98Subventions
Organisme : National Natural Science Foundation of China
ID : 31872475
Organisme : Sichuan Veterinary Medicine and Drug Innovation Group of China Agricultural Research System
ID : CARS-SVDIP
Organisme : China Agricultural Research System
ID : CARS-42-17
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