Expression of ACE2, Soluble ACE2, Angiotensin I, Angiotensin II and Angiotensin-(1-7) Is Modulated in COVID-19 Patients.
Adult
Angiotensin I
/ blood
Angiotensin II
/ blood
Angiotensin-Converting Enzyme 2
/ blood
COVID-19
/ blood
Female
Gene Expression Profiling
HLA-DR Antigens
Humans
Lipopolysaccharide Receptors
Male
Middle Aged
Monocytes
/ immunology
Peptide Fragments
/ blood
Pilot Projects
Prospective Studies
RNA, Messenger
Virus Shedding
ACE2 (Angiotensin Converting Enzyme-2)
COVID-19
Hypertension
Renin – Angiotensin – Aldosterone System
SARS – CoV – 2
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
05
11
2020
accepted:
31
05
2021
entrez:
1
7
2021
pubmed:
2
7
2021
medline:
13
7
2021
Statut:
epublish
Résumé
The etiological agent of COVID-19 SARS-CoV-2, is primarily a pulmonary-tropic coronavirus. Infection of alveolar pneumocytes by SARS-CoV-2 requires virus binding to the angiotensin I converting enzyme 2 (ACE2) monocarboxypeptidase. ACE2, present on the surface of many cell types, is known to be a regulator of blood pressure homeostasis through its ability to catalyze the proteolysis of Angiotensin II (Ang II) into Angiotensin-(1-7) [Ang-(1-7)]. We therefore hypothesized that SARS-CoV-2 could trigger variations of ACE2 expression and Ang II plasma concentration in SARS-CoV-2-infected patients. We report here, that circulating blood cells from COVID-19 patients express less ACE2 mRNA than cells from healthy volunteers. At the level of circulating cells, this
Identifiants
pubmed: 34194422
doi: 10.3389/fimmu.2021.625732
pmc: PMC8236950
doi:
Substances chimiques
CD14 protein, human
0
HLA-DR Antigens
0
Lipopolysaccharide Receptors
0
Peptide Fragments
0
RNA, Messenger
0
Angiotensin II
11128-99-7
Angiotensin I
9041-90-1
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
angiotensin I (1-7)
IJ3FUK8MOF
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
625732Informations de copyright
Copyright © 2021 Osman, Melenotte, Brouqui, Million, Lagier, Parola, Stein, La Scola, Meddeb, Mege, Raoult and Devaux.
Déclaration de conflit d'intérêts
CD declares owning Sanofi and Merck shares. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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