Vapor exposure to Δ9-tetrahydrocannabinol (THC) slows locomotion of the Maine lobster (Homarus americanus).
Administration, Inhalation
Animals
Cooking
/ methods
Dronabinol
/ administration & dosage
E-Cigarette Vapor
/ administration & dosage
Electronic Nicotine Delivery Systems
Female
Hot Temperature
Locomotion
/ drug effects
Maine
Male
Marijuana Smoking
/ metabolism
Nephropidae
Nociception
/ drug effects
Pain
/ drug therapy
Rats
Cannabis
Crustacean
E-cigarette
Nociception
Journal
Pharmacology, biochemistry, and behavior
ISSN: 1873-5177
Titre abrégé: Pharmacol Biochem Behav
Pays: United States
ID NLM: 0367050
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
27
05
2021
revised:
23
06
2021
accepted:
24
06
2021
pubmed:
2
7
2021
medline:
15
2
2022
entrez:
1
7
2021
Statut:
ppublish
Résumé
Despite a long history of use in synaptic physiology, the lobster has been a neglected model for behavioral pharmacology. A restaurateur proposed that exposing lobster to cannabis smoke reduces anxiety and pain during the cooking process. It is unknown if lobster gill respiration in air would result in significant Δ The primary goal was to determine tissue THC levels in the lobster after exposure to THC vapor. Secondary goals were to determine if THC vapor altered locomotor behavior or nociception. Tissue samples were collected (including muscle, brain and hemolymph) from Homarus americanus (N = 3 per group) following 30 or 60 min of exposure to vapor generated by an e-cigarette device using THC (100 mg/mL in a propylene glycol vehicle). Separate experiments assessed locomotor behavior and hot water nociceptive responses following THC vapor exposure. THC vapor produced duration-related THC levels in all tissues examined. Locomotor activity was decreased (distance, speed, time-mobile) by 30 min inhalation of THC. Lobsters exhibit a temperature-dependent withdrawal response to immersion of tail, antennae or claws in warm water; this is novel evidence of thermal nociception for this species. THC exposure for 60 min had only marginal effect on nociception under the conditions assessed. Vapor exposure of lobsters, using an e-cigarette based model, produces dose-dependent THC levels in all tissues and reduces locomotor activity. Hot water nociception was temperature dependent, but only minimal anti-nociceptive effect of THC exposure was confirmed.
Identifiants
pubmed: 34197845
pii: S0091-3057(21)00121-0
doi: 10.1016/j.pbb.2021.173222
pmc: PMC9083469
mid: NIHMS1802860
pii:
doi:
Substances chimiques
E-Cigarette Vapor
0
Dronabinol
7J8897W37S
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
173222Subventions
Organisme : NIDA NIH HHS
ID : R01 DA035281
Pays : United States
Organisme : NIGMS NIH HHS
ID : K12 GM068524
Pays : United States
Organisme : NIAAA NIH HHS
ID : T32 AA007456
Pays : United States
Organisme : NIDA NIH HHS
ID : R44 DA041967
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA035482
Pays : United States
Organisme : NIDA NIH HHS
ID : K99 DA047413
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
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