Evidence for Biological Age Acceleration and Telomere Shortening in COVID-19 Survivors.
Adult
Aged
Aging
/ genetics
Angiotensin-Converting Enzyme 2
/ blood
Biomarkers
COVID-19
/ complications
CpG Islands
DNA Methylation
Dipeptidyl Peptidase 4
/ blood
Epigenomics
Female
High-Throughput Nucleotide Sequencing
Host Microbial Interactions
Humans
Male
Middle Aged
Risk Factors
Survivors
Telomere
/ metabolism
Telomere Shortening
Post-Acute COVID-19 Syndrome
ACE2
COVID-19
DNA methylation
DPP-4
DeltaAge
biological age
epigenetics
post-COVID-19
telomeres
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
07 Jun 2021
07 Jun 2021
Historique:
received:
13
05
2021
revised:
28
05
2021
accepted:
31
05
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
13
7
2021
Statut:
epublish
Résumé
The SARS-CoV-2 infection determines the COVID-19 syndrome characterized, in the worst cases, by severe respiratory distress, pulmonary and cardiac fibrosis, inflammatory cytokine release, and immunosuppression. This condition has led to the death of about 2.15% of the total infected world population so far. Among survivors, the presence of the so-called persistent post-COVID-19 syndrome (PPCS) is a common finding. In COVID-19 survivors, PPCS presents one or more symptoms: fatigue, dyspnea, memory loss, sleep disorders, and difficulty concentrating. In this study, a cohort of 117 COVID-19 survivors (post-COVID-19) and 144 non-infected volunteers (COVID-19-free) was analyzed using pyrosequencing of defined CpG islands previously identified as suitable for biological age determination. The results show a consistent biological age increase in the post-COVID-19 population, determining a DeltaAge acceleration of 10.45 ± 7.29 years (+5.25 years above the range of normality) compared with 3.68 ± 8.17 years for the COVID-19-free population (
Identifiants
pubmed: 34200325
pii: ijms22116151
doi: 10.3390/ijms22116151
pmc: PMC8201243
pii:
doi:
Substances chimiques
Biomarkers
0
Dipeptidyl Peptidase 4
EC 3.4.14.5
ACE2 protein, human
EC 3.4.17.23
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministero dell'Educazione, Università e ricerca
ID : PRIN2017S55RXB
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : PRIN2015HPMLFY
Organisme : Ministero della Salute
ID : RF 2010-2318330
Organisme : Ministero della Salute
ID : "RicercaCorrente" and "Progetto di Rete Cardiovascolare IRCCS: CardioCovid"
Organisme : Fondazione Telethon
ID : 446 GGP19035A
Organisme : Fondazione Telethon
ID : 23054
Organisme : Horizon 2020
ID : 101016072
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : 22858
Références
J Infect Dis. 2015 Nov 15;212(10):1563-73
pubmed: 25969563
Ageing Res Rev. 2013 Mar;12(2):605-17
pubmed: 23454111
Clin Rev Allergy Immunol. 2021 Feb 20;:
pubmed: 33609255
PLoS One. 2017 Aug 3;12(8):e0182422
pubmed: 28771625
EBioMedicine. 2017 Jul;21:29-36
pubmed: 28396265
Mol Cell. 2013 Jan 24;49(2):359-367
pubmed: 23177740
J Neurovirol. 2016 Jun;22(3):366-75
pubmed: 26689571
Lancet HIV. 2021 Apr;8(4):e197-e205
pubmed: 33794182
JCI Insight. 2021 Jan 25;6(2):
pubmed: 33284134
Exp Gerontol. 2015 Dec;72:227-9
pubmed: 26485162
Diabetes Metab Syndr. 2020 May - Jun;14(3):247-250
pubmed: 32247212
Cell Res. 2013 Aug;23(8):986-93
pubmed: 23835475
World J Microbiol Biotechnol. 2016 Jun;32(6):92
pubmed: 27116958
Genome Biol. 2013;14(10):R115
pubmed: 24138928
Cardiovasc Res. 2021 May 25;117(6):1557-1566
pubmed: 33705542
Nat Rev Genet. 2018 Jun;19(6):371-384
pubmed: 29643443
Eur Heart J. 2020 Sep 1;41(33):3198-3199
pubmed: 32691041
Anticancer Res. 2005 Jul-Aug;25(4):3011-21
pubmed: 16080560
Ann Am Thorac Soc. 2021 May;18(5):799-806
pubmed: 33433263
Nat Rev Mol Cell Biol. 2016 Nov;17(11):679-690
pubmed: 27552971
Clin Epigenetics. 2020 Oct 21;12(1):156
pubmed: 33087172
Pharmacol Res. 2017 Nov;125(Pt A):21-38
pubmed: 28619367
Genes (Basel). 2021 Jan 25;12(2):
pubmed: 33503821
Aging (Albany NY). 2021 Jan 11;13(1):1-15
pubmed: 33428591
Nature. 2010 Aug 26;466(7310):1129-33
pubmed: 20639862
Pain Rep. 2021 Feb 16;6(1):e887
pubmed: 33615088
Lancet Infect Dis. 2020 Apr;20(4):425-434
pubmed: 32105637
Genome Biol. 2014 Feb 03;15(2):R24
pubmed: 24490752
Acta Diabetol. 2020 Jul;57(7):779-783
pubmed: 32506195
Aging (Albany NY). 2020 Oct 26;12(20):19911-19922
pubmed: 33104521
Aging (Albany NY). 2020 Mar 30;12(8):6511-6517
pubmed: 32229706
Sci Rep. 2019 Jun 20;9(1):8862
pubmed: 31222117
Mech Ageing Dev. 2018 Sep;174:18-29
pubmed: 29337038
BMB Rep. 2017 Nov;50(11):546-553
pubmed: 28946940
Epigenetics. 2015;10(10):922-30
pubmed: 26280308
Clin Epidemiol. 2012;4:159-69
pubmed: 22866017
Cell Metab. 2020 Sep 1;32(3):447-456.e6
pubmed: 32877690
Curr Opin Cardiol. 2019 May;34(3):270-274
pubmed: 30747731
Forensic Sci Int Genet. 2018 Nov;37:180-195
pubmed: 30176440
Forensic Sci Int Genet. 2016 Sep;24:33-43
pubmed: 27288716
Pharmacol Ther. 2019 Jun;198:135-159
pubmed: 30822465
Thromb Res. 2020 Jul;191:145-147
pubmed: 32291094
EBioMedicine. 2021 Apr;66:103339
pubmed: 33867313
Int J Cardiol. 2020 Jun 15;309:70-77
pubmed: 32248966
Arterioscler Thromb Vasc Biol. 2018 Jul;38(7):e108-e116
pubmed: 29950386
Exp Cell Res. 1961 Dec;25:585-621
pubmed: 13905658
Lancet Diabetes Endocrinol. 2021 Feb;9(2):117-126
pubmed: 33248477
J Clin Med. 2020 Oct 28;9(11):
pubmed: 33126772
Genes Dev. 2017 Aug 1;31(15):1529-1534
pubmed: 28877934