Evidence of Circulation of Several HAV Genetic Variants and Emergence of Potential Antigenic Variants in an Endemo-Epidemic Country before Vaccine Introduction.
Amino Acid Substitution
Antigenic Variation
/ genetics
Cluster Analysis
DNA, Viral
/ genetics
Disease Outbreaks
Genetic Variation
Genotype
Hepatitis A
/ epidemiology
Hepatitis A Vaccines
/ administration & dosage
Hepatitis A virus
/ classification
Humans
Phylogeny
Public Health
RNA, Viral
/ genetics
Retrospective Studies
Sequence Analysis, DNA
Tunisia
/ epidemiology
Viral Proteins
/ genetics
antigenic variant
genotyping
hepatitis A virus
molecular characterization
public health
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
03 06 2021
03 06 2021
Historique:
received:
15
04
2021
revised:
20
05
2021
accepted:
27
05
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
19
1
2022
Statut:
epublish
Résumé
Similar to several other countries in the world, the epidemiology of hepatitis A virus changed from high to intermediate endemicity level in Tunisia, which led to the occurrence of outbreaks. This study aimed to determine the genetic and antigenic variability of HAV strains circulating in Tunisia during the last few years. Genotyping using complete VP1 gene and VP1-2A junction confirmed the predominance of genotype IA, with co-circulation of several genetic and antigenic variants. Phylogenetic analysis including Tunisian and strains from other regions of the world showed the presence of at least two IA-variants within IA subgenotype. Amino-acid analysis showed several mutations in or close to epitope regions in the VP1-region. This study provides a baseline on the genetic and antigenic variability of HAV circulating strains before the introduction of vaccination into the national immunization schedule.
Identifiants
pubmed: 34204862
pii: v13061056
doi: 10.3390/v13061056
pmc: PMC8227776
pii:
doi:
Substances chimiques
DNA, Viral
0
Hepatitis A Vaccines
0
RNA, Viral
0
Viral Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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