Emergence of a Novel Dengue Virus 3 (DENV-3) Genotype-I Coincident with Increased DENV-3 Cases in Yangon, Myanmar between 2017 and 2019.
Adolescent
Amino Acid Substitution
Child
Child, Preschool
Communicable Diseases, Emerging
/ epidemiology
Dengue
/ diagnosis
Dengue Virus
/ classification
Disease Outbreaks
Genetic Variation
Genome, Viral
Genotype
History, 21st Century
Humans
Myanmar
Phylogeny
Seroepidemiologic Studies
Serogroup
Whole Genome Sequencing
DENV-3
Myanmar
co-circulation
dengue outbreak
genotype-1
serotypes
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
16 06 2021
16 06 2021
Historique:
received:
30
04
2021
revised:
07
06
2021
accepted:
11
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
17
8
2021
Statut:
epublish
Résumé
Dengue fever, caused by the mosquito-borne dengue virus (DENV), has been endemic in Myanmar since 1970 and it has become a significant public health burden. It is crucial that circulating DENV strains are identified and monitored, and that their transmission efficiency and association with disease severity is understood. In this study, we analyzed DENV-1, DENV-2, DENV-3, and DENV-4 serotypes in 1235 serum samples collected in Myanmar between 2017 and 2019. Whole-genome sequencing of DENV-1-4 demonstrated that most DENV-1-4 strains had been circulating in Myanmar for several years. We also identified the emergence of DENV-3 genotype-I in 2017 samples, which persisted through 2018 and 2019. The emergence of the strain coincided with a period of increased DENV-3 cases and marked changes in the serotype dynamics. Nevertheless, we detected no significant differences between serum viral loads, disease severity, and infection status of individuals infected with different DENV serotypes during the 3-year study. Our results not only identify the spread of a new DENV-3 genotype into Yangon, Myanmar, but also support the importance of DENV evolution in changing the epidemic dynamics in endemic regions.
Identifiants
pubmed: 34208667
pii: v13061152
doi: 10.3390/v13061152
pmc: PMC8235066
pii:
doi:
Types de publication
Historical Article
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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