Infant T-cell acute lymphoblastic leukaemia with t(6;7) (TCRB-MYB) translocation.
T-Acute Lymphoblastic Leukaemia
infant
Journal
British journal of haematology
ISSN: 1365-2141
Titre abrégé: Br J Haematol
Pays: England
ID NLM: 0372544
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
revised:
05
05
2021
received:
07
04
2021
accepted:
11
05
2021
pubmed:
3
7
2021
medline:
15
12
2021
entrez:
2
7
2021
Statut:
ppublish
Résumé
T-ALL is rare in infancy with only 10 (1.5%) of 651 patients of that subtype in the Interfant-06 infant ALL trial. We report 3 cases of t(6;7) (TCR/MYB) infant T-cell Acute Lymphoblastic Leukaemia who appear to have a distinct clinical presentation with CNS disease and refractory disease or late relapse.
Substances chimiques
MYB protein, human
0
Proto-Oncogene Proteins c-myb
0
Receptors, Antigen, T-Cell, alpha-beta
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
613-616Informations de copyright
© 2021 British Society for Haematology and John Wiley & Sons Ltd.
Références
Pieters R, Lorenzo P, Ancliff P, Aversa LA, Brethon B, Biondi A, et al. Outcome of infants younger than 1 year with acute lymphoblastic leukaemia treated with Interfant-06 protocol: results from an international phase III randomised study. J Clin Oncol. 2019;37, 2246-56.
Mansur M, Delft F, Colman S, Furness CL, Gibson J, Emerenciano M, et al. Distinctive genotype in infants with T- cell acute lymphoblastic leukaemia. British J Haematol. 2015;171:574-84
Clappier E, Cuccuini W, Kalota A, Crinquette A, Cayuela JM, Dik WA, et al. The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukaemia (T-ALL), the translocation defining a new T-ALL subtype in very young children. Blood. 2007;110:1251-61.
Homminga I, Pieters R, Langerak A, de Rooi J, Stubbs A, Verstegen M, et al. Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia. Cancer Cell. 2011;19:484-97.