Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy.
Adult
Amino Acid Sequence
Animals
Base Sequence
CD28 Antigens
/ deficiency
CD4-Positive T-Lymphocytes
/ immunology
Child
Endopeptidases
/ metabolism
Female
Genes, Recessive
HEK293 Cells
Homozygote
Humans
Immunity, Humoral
Immunologic Memory
Inheritance Patterns
/ genetics
Jurkat Cells
Keratinocytes
/ pathology
Male
Mice, Inbred C57BL
Oncogenes
Papilloma
/ pathology
Papillomaviridae
/ physiology
Pedigree
Protein Sorting Signals
RNA, Messenger
/ genetics
Skin
/ virology
T-Lymphocytes
/ immunology
CD28
HPV
T cell
cutaneous horn
immunodeficiency
oncogene
papillomavirus
somatic reversion
tree man syndrome
wart
Journal
Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066
Informations de publication
Date de publication:
08 07 2021
08 07 2021
Historique:
received:
17
10
2020
revised:
03
02
2021
accepted:
02
06
2021
pubmed:
3
7
2021
medline:
4
1
2022
entrez:
2
7
2021
Statut:
ppublish
Résumé
We study a patient with the human papilloma virus (HPV)-2-driven "tree-man" phenotype and two relatives with unusually severe HPV4-driven warts. The giant horns form an HPV-2-driven multifocal benign epithelial tumor overexpressing viral oncogenes in the epidermis basal layer. The patients are unexpectedly homozygous for a private CD28 variant. They have no detectable CD28 on their T cells, with the exception of a small contingent of revertant memory CD4
Identifiants
pubmed: 34214472
pii: S0092-8674(21)00705-4
doi: 10.1016/j.cell.2021.06.004
pmc: PMC8329841
mid: NIHMS1717953
pii:
doi:
Substances chimiques
CD28 Antigens
0
Protein Sorting Signals
0
RNA, Messenger
0
Endopeptidases
EC 3.4.-
USP37 protein, human
EC 3.4.99.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3812-3828.e30Subventions
Organisme : Medical Research Council
ID : MC_U117584278
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_13050
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : U19 AI057229
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001866
Pays : United States
Organisme : Medical Research Council
ID : MR/S024409/1
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R01 AI143810
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests L.D.N. receives compensation as Chief Editor of Frontiers in Immunology. T.W. serves on advisory boards for MSD (Merck Sharp and Dohme). J.-L.C. serves on the scientific advisory boards of ADMA Biologics Inc., Kymera Therapeutics, and Elixiron Immunotherapeutics. All other authors declare no competing interests.
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