Insulin Directly Regulates the Circadian Clock in Adipose Tissue.
3T3-L1 Cells
Adipocytes
/ drug effects
Adipose Tissue
/ drug effects
Animals
Circadian Clocks
/ drug effects
Circadian Rhythm
/ drug effects
Humans
Insulin
/ pharmacology
Mesenchymal Stem Cells
/ drug effects
Mice
Nuclear Receptor Subfamily 1, Group D, Member 1
/ genetics
Period Circadian Proteins
/ genetics
Promoter Regions, Genetic
/ drug effects
Journal
Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
10
09
2020
accepted:
15
06
2021
pubmed:
7
7
2021
medline:
9
11
2021
entrez:
6
7
2021
Statut:
ppublish
Résumé
Adipose tissue (AT) is a key metabolic organ which functions are rhythmically regulated by an endogenous circadian clock. Feeding is a "zeitgeber" aligning the clock in AT with the external time, but mechanisms of this regulation remain largely unclear. We tested the hypothesis that postprandial changes of the hormone insulin directly entrain circadian clocks in AT and investigated a transcriptional-dependent mechanism of this regulation. We analyzed gene expression in subcutaneous AT (SAT) of obese subjects collected before and after the hyperinsulinemic-euglycemic clamp or control saline infusion (SC). The expressions of core clock genes
Identifiants
pubmed: 34226282
pii: db20-0910
doi: 10.2337/db20-0910
doi:
Substances chimiques
Insulin
0
NR1D1 protein, human
0
Nuclear Receptor Subfamily 1, Group D, Member 1
0
PER2 protein, human
0
PER3 protein, human
0
Period Circadian Proteins
0
Banques de données
ClinicalTrials.gov
['NCT00774488']
figshare
['10.2337/figshare.14791830']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1985-1999Informations de copyright
© 2021 by the American Diabetes Association.