Immunomodulatory properties of characellide A on human peripheral blood mononuclear cells.
CD1d
IL-6
LPS
Simplexide
TNF-α
Journal
Inflammopharmacology
ISSN: 1568-5608
Titre abrégé: Inflammopharmacology
Pays: Switzerland
ID NLM: 9112626
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
15
04
2021
accepted:
16
06
2021
pubmed:
10
7
2021
medline:
1
1
2022
entrez:
9
7
2021
Statut:
ppublish
Résumé
Marine sponges and their associated microbiota are multicellular animals known to produce metabolites with interesting pharmacological properties playing a pivotal role against a plethora of pathologic disorders such as inflammation, cancer and infections. Characellide A and B belong to a novel class of glycolipopeptides isolated from the deep sea marine sponge Characella pachastrelloides. In this study, we have evaluated the effects of characellide A and B on cytokine and chemokine release from human peripheral blood mononuclear cells (PBMC). Characellide A induces a concentration- and time-dependent CXCL8, IL-6 and TNF-α release from PBMC. This production is mediated by the induction of gene transcription. Moreover, cytokine/chemokine release induced by characellide A from PBMC is CD1d-dependent because a CD1d antagonist, 1,2-bis(diphenylphosphino)ethane [DPPE]-polyethylene glycolmonomethylether [PEG], specifically inhibits characellide A-induced activation of PBMC. In conclusion, characellide A is a novel modulator of adaptative/innate immune responses. Further studies are needed to understand its potential pharmacological application.
Identifiants
pubmed: 34241784
doi: 10.1007/s10787-021-00836-5
pii: 10.1007/s10787-021-00836-5
pmc: PMC8298336
doi:
Substances chimiques
Biological Factors
0
Immunomodulating Agents
0
Inflammation Mediators
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1201-1210Subventions
Organisme : Science Foundation Ireland and the Marine Institute under the Investigators Programme Grant
ID : SFI/15/IA/3100
Informations de copyright
© 2021. The Author(s).
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