Antibiotic-driven intestinal dysbiosis in pediatric short bowel syndrome is associated with persistently altered microbiome functions and gut-derived bloodstream infections.
Short bowel syndrome
antibiotics
bloodstream infections
functional profiling
intestinal dysbiosis
microbiota
shotgun metagenomics
strain-tracking
Journal
Gut microbes
ISSN: 1949-0984
Titre abrégé: Gut Microbes
Pays: United States
ID NLM: 101495343
Informations de publication
Date de publication:
Historique:
entrez:
15
7
2021
pubmed:
16
7
2021
medline:
22
12
2021
Statut:
ppublish
Résumé
Surgical removal of the intestine, lifesaving in catastrophic gastrointestinal disorders of infancy, can result in a form of intestinal failure known as short bowel syndrome (SBS). Bloodstream infections (BSIs) are a major challenge in pediatric SBS management. BSIs require frequent antibiotic therapy, with ill-defined consequences for the gut microbiome and childhood health. Here, we combine serial stool collection, shotgun metagenomic sequencing, multivariate statistics and genome-resolved strain-tracking in a cohort of 19 patients with surgically-induced SBS to show that antibiotic-driven intestinal dysbiosis in SBS enriches for persistent intestinal colonization with BSI causative pathogens in SBS. Comparing the gut microbiome composition of SBS patients over the first 4 years of life to 19 age-matched term and 18 preterm controls, we find that SBS gut microbiota diversity and composition was persistently altered compared to controls. Commensals including
Identifiants
pubmed: 34264786
doi: 10.1080/19490976.2021.1940792
pmc: PMC8284144
doi:
Substances chimiques
Anti-Bacterial Agents
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1940792Subventions
Organisme : NIAID NIH HHS
ID : U01 AI131342
Pays : United States
Organisme : NIAID NIH HHS
ID : UH3 AI083265
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI123394
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD092414
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK052574
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK112378
Pays : United States
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