Plasticity of Mature B Cells Between Follicular and Classic Hodgkin Lymphomas: A Series of 22 Cases Expanding the Spectrum of Transdifferentiation.
Aged
Aged, 80 and over
B-Lymphocytes
/ immunology
Biomarkers, Tumor
/ genetics
Cell Plasticity
DNA Mutational Analysis
Female
France
Gene Rearrangement, B-Lymphocyte, Heavy Chain
High-Throughput Nucleotide Sequencing
Hodgkin Disease
/ drug therapy
Humans
Immunoglobulin Heavy Chains
Immunoglobulins
/ genetics
Immunohistochemistry
In Situ Hybridization, Fluorescence
Lymphoma, Follicular
/ drug therapy
Male
Middle Aged
Mutation
Phenotype
Polymerase Chain Reaction
Proto-Oncogene Proteins c-bcl-2
/ genetics
Proto-Oncogene Proteins c-bcl-6
/ genetics
Retrospective Studies
Journal
The American journal of surgical pathology
ISSN: 1532-0979
Titre abrégé: Am J Surg Pathol
Pays: United States
ID NLM: 7707904
Informations de publication
Date de publication:
01 01 2022
01 01 2022
Historique:
pubmed:
16
7
2021
medline:
15
2
2022
entrez:
15
7
2021
Statut:
ppublish
Résumé
Follicular lymphoma and classic Hodgkin lymphoma can be associated in composite and/or sequential lymphomas. Common IGH and BCL2 rearrangements have already been identified between both contingents of these entities, but mutation profiles have not yet been investigated. The main objective of this study was to analyze the transdifferentiation process that may occur between Hodgkin and follicular contingents in sequential and composite lymphomas to better characterize these entities. From 2004 to 2020, a retrospective multicentric study was performed, including 9 composite and 13 sequential lymphomas. Clinical data were retrospectively collected. Fluorescent in situ hybridization of BCL2 and BCL6 rearrangements, polymerase chain reaction of IGH and IGK rearrangements, next-generation sequencing of IGK rearrangement, and targeted next-generation sequencing (TNGS) on a panel of genes frequently mutated in lymphomas were performed on each contingent of composite and sequential lymphomas. For TNGS, each contingent was isolated by laser capture microdissection. Clinical presentation and evolution were more aggressive in sequential than composite lymphomas. By fluorescent in situ hybridization, common rearrangements of BCL6 and BCL2 were identified between both contingents. Similarly, a common clonal relationship was established by evaluating IGH and IGK rearrangement by polymerase chain reaction or next-generation sequencing. By TNGS, the same pathogenic variants were identified in both contingents in the following genes: CREBBP, KMT2D, BCL2, EP300, SF3B1, SOCS1, ARID1A, and BCOR. Specific pathogenic variants for each contingent were also identified: XPO1 for Hodgkin lymphoma contingent and FOXO1, TNFRSF14 for follicular lymphoma contingent. This study reinforces the hypothesis of a transdifferentiation process between Hodgkin and follicular contingent of sequential/composite lymphomas.
Identifiants
pubmed: 34265801
doi: 10.1097/PAS.0000000000001780
pii: 00000478-202201000-00014
doi:
Substances chimiques
BCL2 protein, human
0
BCL6 protein, human
0
Biomarkers, Tumor
0
IgK
0
Immunoglobulin Heavy Chains
0
Immunoglobulins
0
Proto-Oncogene Proteins c-bcl-2
0
Proto-Oncogene Proteins c-bcl-6
0
Types de publication
Comparative Study
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
58-70Informations de copyright
Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of Interest and Source of Funding: The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article.
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