Nuclear Protein Condensates and Their Properties in Regulation of Gene Expression.
biomolecular condensates
chromatin and transcription
gene expression
liquid-liquid phase separation
material properties
Journal
Journal of molecular biology
ISSN: 1089-8638
Titre abrégé: J Mol Biol
Pays: Netherlands
ID NLM: 2985088R
Informations de publication
Date de publication:
15 01 2022
15 01 2022
Historique:
received:
06
05
2021
revised:
01
07
2021
accepted:
06
07
2021
pubmed:
17
7
2021
medline:
29
1
2022
entrez:
16
7
2021
Statut:
ppublish
Résumé
Our understanding of the spatiotemporal regulation of eukaryotic gene expression has recently been greatly stimulated by the findings that many of the regulators of chromatin, transcription, and RNA processing form biomolecular condensates often assembled through liquid-liquid phase separation. Increasing number of reports suggest that these condensates functionally regulate gene expression, largely by concentrating the relevant biomolecules in the liquid-like micro-compartments. However, it remains poorly understood how the physicochemical properties, especially the material properties, of the condensates regulate gene expression activity. In this review, we discuss current data on various nuclear condensates and their biophysical properties with the underlying molecular interactions, and how they may functionally impact gene expression at the level of chromatin organization and activities, transcription, and RNA processing.
Identifiants
pubmed: 34271007
pii: S0022-2836(21)00380-6
doi: 10.1016/j.jmb.2021.167151
pmc: PMC9012237
mid: NIHMS1790665
pii:
doi:
Substances chimiques
Chromatin
0
Nuclear Proteins
0
RNA Polymerase II
EC 2.7.7.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
167151Subventions
Organisme : NCI NIH HHS
ID : R21 CA257936
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
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