Epitope Mapping of the Anti-CD44 Monoclonal Antibody (C

Animals Antibodies, Monoclonal Epitope Mapping Hyaluronan Receptors / genetics Mice Neoplasms Protein Isoforms / genetics
CD44 REMAP method epitope mapping monoclonal antibody

Journal

Monoclonal antibodies in immunodiagnosis and immunotherapy
ISSN: 2167-9436
Titre abrégé: Monoclon Antib Immunodiagn Immunother
Pays: United States
ID NLM: 101590955

Informations de publication

Date de publication:
Aug 2021
Historique:
pubmed: 21 7 2021
medline: 14 1 2022
entrez: 20 7 2021
Statut: ppublish

Résumé

CD44 functions as a major hyaluronan receptor on most cell types, with roles in cell adhesion, migration, proliferation, differentiation, and survival. The CD44 gene comprises 20 exons, with alternative splicing producing many different isoforms. CD44 variant isoforms exhibit tissue-specific expression patterns and have been studied as therapeutic targets for several cancers; therefore, anti-CD44 monoclonal antibodies (mAbs) are useful for investigating CD44 expression in various cancers. Previously, we established an anti-CD44 mAb, C

Identifiants

DOI: 10.1089/mab.2021.0012 PMID: 34283655
pubmed: 34283655
doi: 10.1089/mab.2021.0012
doi:

Substances chimiques

Antibodies, Monoclonal 0
Hyaluronan Receptors 0
Protein Isoforms 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

156-161

Auteurs

Teizo Asano (T)

Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Japan.

Mika K Kaneko (MK)

Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Japan.

Junko Takei (J)

Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Japan.

Nami Tateyama (N)

Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Japan.

Yukinari Kato (Y)

Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Japan.
Department of Molecular Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Japan.
ORCID: 0000-0001-5385-8201

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Epitope Mapping of the Anti-CD44 Monoclonal Antibody (C
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps monoclonaux › Epitope Mapping of the Anti-CD44 Monoclonal Antibody (C
questionsmedicales.fr › Techniques d'investigation › Techniques de sonde moléculaire › Cartographie d'interactions entre protéines › Cartographie épitopique › Epitope Mapping of the Anti-CD44 Monoclonal Antibody (C
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes de surface › Molécules d'adhérence cellulaire › Récepteurs d'écotaxie des lymphocytes › Antigènes CD44 › Epitope Mapping of the Anti-CD44 Monoclonal Antibody (C
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Epitope Mapping of the Anti-CD44 Monoclonal Antibody (C
questionsmedicales.fr › Tumeurs › Epitope Mapping of the Anti-CD44 Monoclonal Antibody (C
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Isoformes de protéines › Epitope Mapping of the Anti-CD44 Monoclonal Antibody (C