Cardiovascular disease in diabetes, beyond glucose.
Journal
Cell metabolism
ISSN: 1932-7420
Titre abrégé: Cell Metab
Pays: United States
ID NLM: 101233170
Informations de publication
Date de publication:
03 08 2021
03 08 2021
Historique:
received:
23
02
2021
revised:
21
05
2021
accepted:
01
07
2021
pubmed:
22
7
2021
medline:
8
4
2022
entrez:
21
7
2021
Statut:
ppublish
Résumé
Despite the decades-old knowledge that diabetes mellitus is a major risk factor for cardiovascular disease, the reasons for this association are only partially understood. While this association is true for both type 1 and type 2 diabetes, different pathophysiological processes may be responsible. Lipids and other risk factors are indeed important, whereas the role of glucose is less clear. This lack of clarity stems from clinical trials that do not unambiguously show that intensive glycemic control reduces cardiovascular events. Animal models have provided mechanisms that link diabetes to increased atherosclerosis, and evidence consistent with the importance of factors beyond hyperglycemia has emerged. We review clinical, pathological, and animal studies exploring the pathogenesis of atherosclerosis in humans living with diabetes and in mouse models of diabetes. An increased effort to identify risk factors beyond glucose is now needed to prevent the increased cardiovascular disease risk associated with diabetes.
Identifiants
pubmed: 34289375
pii: S1550-4131(21)00317-X
doi: 10.1016/j.cmet.2021.07.001
pmc: PMC8411849
mid: NIHMS1725174
pii:
doi:
Substances chimiques
Blood Glucose
0
Hypoglycemic Agents
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1519-1545Subventions
Organisme : NHLBI NIH HHS
ID : R35 HL150754
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL149685
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL045095
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG061549
Pays : United States
Organisme : NHLBI NIH HHS
ID : R37 HL045095
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL116276
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS102506
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK017047
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL073029
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL151328
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests R.H.E. serves as a consultant for Kowa Corp. and Novo Nordisk. K.E.B. has received research support from Novo Nordisk A/S. I.J.G. has served as a consultant for Arrowhead, Akcea, and Esperion and received research support for pre-clinical studies from Arrowhead Pharma.
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