Frequency, variations, and prognostic implications of chromosome 14q32 deletions in chronic lymphocytic leukemia.
5’-Partial IGH (14q32) deletions
CLL prognosis
Fluorescence-in-situ hybridization
LINC00221
SNP array
Journal
Leukemia research
ISSN: 1873-5835
Titre abrégé: Leuk Res
Pays: England
ID NLM: 7706787
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
13
03
2021
revised:
02
07
2021
accepted:
09
07
2021
pubmed:
23
7
2021
medline:
30
11
2021
entrez:
22
7
2021
Statut:
ppublish
Résumé
The clinical implications of deletions within chromosome 14q32 in CLL pathogenesis remain unclear. We examined the frequency of 14q32 deletions among CLL cases by karyotype and FISH, categorized the variation using genomic microarray, and assessed the prognostic impact by time-to-first-treatment (TTFT) analysis. A 14q32 abnormality was detected in 35 % (245/698) of cases, with the majority containing a 5' partial telomeric 14q32 deletion. These deletions within the IGH variable region (35/40) ranged from 236 kb to 1.4 Mb involving FAM30A, ADAM6, LINC00226, and LINC00221. The 214 kb minimum deleted region implicated in CLL pathogenesis encompassed LINC00221. Cases with a 14q32 deletion had a shorter median TTFT compared to cases with a sole deletion/nullisomy 13q, a good prognostic indicator, and longer than cases with a sole deletion of 11q or 17p, conferring an unfavorable prognosis. This investigation underscores the importance of comprehensive testing to apprehend the implications of 14q32 deletions in CLL.
Identifiants
pubmed: 34293710
pii: S0145-2126(21)00166-1
doi: 10.1016/j.leukres.2021.106665
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
106665Informations de copyright
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