Study of Substituted Phenethylamine Fragmentation Induced by Electrospray Ionization Mass Spectrometry and Its Application for Highly Sensitive Analysis of Neurotransmitters in Biological Samples.
Animals
Brain Chemistry
Chemical Fractionation
Chromatography, Liquid
Dopamine
/ analysis
Male
Mice, Inbred C57BL
Neurotransmitter Agents
/ analysis
Norepinephrine
/ analysis
Phenethylamines
/ analysis
Sensitivity and Specificity
Spectrometry, Mass, Electrospray Ionization
/ methods
Tandem Mass Spectrometry
/ methods
Tyramine
/ analysis
Catecholamine
DFT
ESI in-source CID
RRKM
Survival yield
Journal
Journal of the American Society for Mass Spectrometry
ISSN: 1879-1123
Titre abrégé: J Am Soc Mass Spectrom
Pays: United States
ID NLM: 9010412
Informations de publication
Date de publication:
04 Aug 2021
04 Aug 2021
Historique:
pubmed:
24
7
2021
medline:
4
1
2022
entrez:
23
7
2021
Statut:
ppublish
Résumé
Although liquid chromatography-tandem mass spectrometry (LC-MS/MS) equipped with electrospray ionization (ESI) is widely employed for metabolite analysis, substituted phenethylamines commonly undergo fragmentation during ESI in-source collision-induced dissociation (CID). Unexpected fragmentation hampers not only unambiguous identification but also accurate metabolite quantification. ESI in-source CID induces N-C
Identifiants
pubmed: 34293862
doi: 10.1021/jasms.1c00173
doi:
Substances chimiques
Neurotransmitter Agents
0
Phenethylamines
0
Dopamine
VTD58H1Z2X
Norepinephrine
X4W3ENH1CV
Tyramine
X8ZC7V0OX3
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM