Identification and Optimization of a Minor Allele-Specific siRNA to Prevent PNPLA3 I148M-Driven Nonalcoholic Fatty Liver Disease.

Alleles Animals Genome-Wide Association Study Lipase / genetics Liver Membrane Proteins / genetics Mice Non-alcoholic Fatty Liver Disease / genetics Phospholipases A2, Calcium-Independent RNA, Small Interfering / genetics
NAFLD NASH PNPLA3 I148M siRNA

Journal

Nucleic acid therapeutics
ISSN: 2159-3345
Titre abrégé: Nucleic Acid Ther
Pays: United States
ID NLM: 101562758

Informations de publication

Date de publication:
10 2021
Historique:
pubmed: 24 7 2021
medline: 14 1 2022
entrez: 23 7 2021
Statut: ppublish

Résumé

Human genome wide association studies confirm the association of the rs738409 single nucleotide polymorphism (SNP) in the gene encoding protein patatin like phospholipase domain containing 3 (

Identifiants

DOI: 10.1089/nat.2021.0026 PMID: 34297902
pubmed: 34297902
doi: 10.1089/nat.2021.0026
doi:

Substances chimiques

Membrane Proteins 0
RNA, Small Interfering 0
Lipase EC 3.1.1.3
PNPLA3 protein, mouse EC 3.1.1.3
Phospholipases A2, Calcium-Independent EC 3.1.1.4

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

324-340

Auteurs

Justin K Murray (JK)

Therapeutic Discovery, Amgen Research, Thousand Oaks, California, USA.

Jason Long (J)

Therapeutic Discovery, Amgen Research, Thousand Oaks, California, USA.

Lei Liu (L)

Cardiometabolic Disorders, Amgen Research, South San Francisco, California, USA.

Shivani Singh (S)

Cardiometabolic Disorders, Amgen Research, South San Francisco, California, USA.

Danielle Pruitt (D)

Cardiometabolic Disorders, Amgen Research, South San Francisco, California, USA.

Michael Ollmann (M)

Genome Analysis Unit, Amgen Research, South San Francisco, California, USA.

Elissa Swearingen (E)

Genome Analysis Unit, Amgen Research, South San Francisco, California, USA.

Miki Hardy (M)

Genome Analysis Unit, Amgen Research, South San Francisco, California, USA.

Oliver Homann (O)

Genome Analysis Unit, Amgen Research, South San Francisco, California, USA.

Bin Wu (B)

Therapeutic Discovery, Amgen Research, Thousand Oaks, California, USA.

Jerry Ryan Holder (JR)

Therapeutic Discovery, Amgen Research, Thousand Oaks, California, USA.

Kelvin Sham (K)

Therapeutic Discovery, Amgen Research, Thousand Oaks, California, USA.

Brad Herberich (B)

Therapeutic Discovery, Amgen Research, Thousand Oaks, California, USA.

Mei-Chu Lo (MC)

Therapeutic Discovery, Amgen Research, South San Francisco, California, USA.

Hui Dou (H)

Therapeutic Discovery, Amgen Research, South San Francisco, California, USA.

Artem Shkumatov (A)

Translational Safety and Bioanalytical Sciences, Amgen Research, South San Francisco, California, USA.

Monica Florio (M)

Cardiometabolic Disorders, Amgen Research, Thousand Oaks, California, USA.

Ingrid C Rulifson (IC)

Cardiometabolic Disorders, Amgen Research, South San Francisco, California, USA.
ORCID: 0000-0003-3251-3989

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Allèles › Identification and Optimization of a Minor...
questionsmedicales.fr › Eucaryotes › Animaux › Identification and Optimization of a Minor...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Identification and Optimization of a Minor...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Triacylglycerol lipase › Identification and Optimization of a Minor...
questionsmedicales.fr › Système digestif › Foie › Identification and Optimization of a Minor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Identification and Optimization of a Minor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Identification and Optimization of a Minor...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Stéatose hépatique › Stéatose hépatique non alcoolique › Identification and Optimization of a Minor...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Phospholipases A › Phospholipases A2 › Calcium-independent phospholipase A2 › Identification and Optimization of a Minor...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › Petit ARN interférent › Identification and Optimization of a Minor...