Copper(II) complexes based on thiosemicarbazone ligand: Preparation, crystal structure, Hirshfeld surface, energy framework, antiMycobacterium activity, in silico and molecular docking studies.
Antitubercular Agents
/ chemical synthesis
Bacterial Proteins
/ metabolism
Coordination Complexes
/ chemical synthesis
Copper
/ chemistry
Ligands
Microbial Sensitivity Tests
Molecular Docking Simulation
Molecular Structure
Mycobacterium avium
/ drug effects
Mycobacterium kansasii
/ drug effects
Mycobacterium tuberculosis
/ drug effects
Protein Binding
Structure-Activity Relationship
Thermodynamics
Thiosemicarbazones
/ chemical synthesis
Antimycobacterial activity
Copper(II)
Hirshfeld surfaces
Molecular docking
Thiosemicarbazones
X-ray crystallographic analysis
Journal
Journal of inorganic biochemistry
ISSN: 1873-3344
Titre abrégé: J Inorg Biochem
Pays: United States
ID NLM: 7905788
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
06
04
2021
revised:
01
07
2021
accepted:
11
07
2021
pubmed:
24
7
2021
medline:
8
2
2022
entrez:
23
7
2021
Statut:
ppublish
Résumé
Considering the promising previous results on the remarkable activity exhibited by cobalt(III) and manganese(II) thiosemicarbazone compounds as antibacterial agents, the present study aimed to prepare and then evaluate the antibacterial activity of two different types of Cu(II) complexes based on a 2-acetylpyridine-N(4)-methyl-thiosemicarbazone ligand (Hatc-Me), a monomer complex [CuCl(atc-Me)] and a novel dinuclear complex [{Cu(μ-atc-Me)}
Identifiants
pubmed: 34298306
pii: S0162-0134(21)00190-2
doi: 10.1016/j.jinorgbio.2021.111543
pii:
doi:
Substances chimiques
Antitubercular Agents
0
Bacterial Proteins
0
Coordination Complexes
0
Ligands
0
Thiosemicarbazones
0
Copper
789U1901C5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
111543Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.