Calcium and Heart Failure: How Did We Get Here and Where Are We Going?
Adenosine Triphosphatases
/ metabolism
Adrenergic beta-1 Receptor Agonists
/ pharmacology
Adrenergic beta-Antagonists
/ pharmacology
Animals
Antioxidants
/ pharmacology
Ca(2+) Mg(2+)-ATPase
/ metabolism
Calcium
/ metabolism
Calcium-Calmodulin-Dependent Protein Kinase Type 2
/ antagonists & inhibitors
Cardiotonic Agents
/ pharmacology
Dobutamine
/ pharmacology
Heart Failure
/ drug therapy
Humans
Myocardial Contraction
/ physiology
Sarcoplasmic Reticulum
/ metabolism
beta blocker
calcium transient
excitation–contraction coupling
heart failure
hypoxia
inotrope
myocardial contractility
myofilament
sarcoplasmic reticulum
sarcoplasmic reticulum Ca2+ ATPase
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
09 Jul 2021
09 Jul 2021
Historique:
received:
06
06
2021
revised:
23
06
2021
accepted:
30
06
2021
entrez:
24
7
2021
pubmed:
25
7
2021
medline:
11
8
2021
Statut:
epublish
Résumé
The occurrence and prevalence of heart failure remain high in the United States as well as globally. One person dies every 30 s from heart disease. Recognizing the importance of heart failure, clinicians and scientists have sought better therapeutic strategies and even cures for end-stage heart failure. This exploration has resulted in many failed clinical trials testing novel classes of pharmaceutical drugs and even gene therapy. As a result, along the way, there have been paradigm shifts toward and away from differing therapeutic approaches. The continued prevalence of death from heart failure, however, clearly demonstrates that the heart is not simply a pump and instead forces us to consider the complexity of simplicity in the pathophysiology of heart failure and reinforces the need to discover new therapeutic approaches.
Identifiants
pubmed: 34299010
pii: ijms22147392
doi: 10.3390/ijms22147392
pmc: PMC8306046
pii:
doi:
Substances chimiques
Adrenergic beta-1 Receptor Agonists
0
Adrenergic beta-Antagonists
0
Antioxidants
0
Cardiotonic Agents
0
Dobutamine
3S12J47372
Calcium-Calmodulin-Dependent Protein Kinase Type 2
EC 2.7.11.17
Adenosine Triphosphatases
EC 3.6.1.-
Ca(2+) Mg(2+)-ATPase
EC 3.6.1.-
Calcium
SY7Q814VUP
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : R01HL49574; R01HL49574; R01HL39091; R01HL97979; R01HL133294
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL157116
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL133294
Pays : United States
Organisme : Prince Mahidol Award Foundation, Thailand
ID : PMAYP
Organisme : American Heart Association
ID : 19TPA34900003
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