Decreased thalamo-cortico connectivity during an implicit sequence motor learning task and 7 days escitalopram intake.
Adult
Cerebellum
/ diagnostic imaging
Citalopram
/ administration & dosage
Female
Humans
Learning
/ drug effects
Magnetic Resonance Imaging
Male
Motor Neurons
/ drug effects
Nerve Net
/ diagnostic imaging
Neuronal Plasticity
/ drug effects
Putamen
/ diagnostic imaging
Selective Serotonin Reuptake Inhibitors
/ administration & dosage
Thalamus
/ diagnostic imaging
Young Adult
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
23 07 2021
23 07 2021
Historique:
received:
08
01
2021
accepted:
05
07
2021
entrez:
24
7
2021
pubmed:
25
7
2021
medline:
28
10
2021
Statut:
epublish
Résumé
Evidence suggests that selective serotonin reuptake inhibitors (SSRIs) reorganize neural networks via a transient window of neuroplasticity. While previous findings support an effect of SSRIs on intrinsic functional connectivity, little is known regarding the influence of SSRI-administration on connectivity during sequence motor learning. To investigate this, we administered 20 mg escitalopram or placebo for 1-week to 60 healthy female participants undergoing concurrent functional magnetic resonance imaging and sequence motor training in a double-blind randomized controlled design. We assessed task-modulated functional connectivity with a psycho-physiological interaction (PPI) analysis in the thalamus, putamen, cerebellum, dorsal premotor, primary motor, supplementary motor, and dorsolateral prefrontal cortices. Comparing an implicit sequence learning condition to a control learning condition, we observed decreased connectivity between the thalamus and bilateral motor regions after 7 days of escitalopram intake. Additionally, we observed a negative correlation between plasma escitalopram levels and PPI connectivity changes, with higher escitalopram levels being associated with greater thalamo-cortico decreases. Our results suggest that escitalopram enhances network-level processing efficiency during sequence motor learning, despite no changes in behaviour. Future studies in more diverse samples, however, with quantitative imaging of neurochemical markers of excitation and inhibition, are necessary to further assess neural responses to escitalopram.
Identifiants
pubmed: 34301974
doi: 10.1038/s41598-021-94009-7
pii: 10.1038/s41598-021-94009-7
pmc: PMC8302647
doi:
Substances chimiques
Serotonin Uptake Inhibitors
0
Citalopram
0DHU5B8D6V
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
15060Informations de copyright
© 2021. The Author(s).
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